Mapping a syntenic modifier on mouse chromosome 1 influencing the expressivity of the compact phenotype in the myostatin mutant (Mstn Cmpt-dl1Abc) compact mouse

László Varga; Orsolya Pinke; Géza Müller; Balázs Kovács; Edit Korom; Gyula Szabó; Morris Soller

doi:10.1534/genetics.104.034033

Mapping a syntenic modifier on mouse chromosome 1 influencing the expressivity of the compact phenotype in the myostatin mutant (Mstn ^Cmpt-dl1Abc) compact mouse

László Varga^*
, Orsolya Pinke
, Géza Müller
, Balázs Kovács
, Edit Korom
, Gyula Szabó
, Morris Soller

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A novel method for mapping a modifier gene that is syntenic to its major gene was used to map a male-sex-limited modifier of the expressivity of the Compact phenotype in the myostatin mutant (Mstn^Cmpt-dl1Abc) Compact mouse. The modifier was mapped to the general region of D1Mit262, 40 cM distal to Mstn on chromosome 1. Myogenin, a postulated downstream target of myostatin, maps to the same region.

Original language	English
Pages (from-to)	489-493
Number of pages	5
Journal	Genetics
Volume	169
Issue number	1
DOIs	https://doi.org/10.1534/genetics.104.034033
State	Published - Jan 2005

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AU - Varga, László

AU - Pinke, Orsolya

AU - Müller, Géza

AU - Kovács, Balázs

AU - Korom, Edit

AU - Szabó, Gyula

AU - Soller, Morris

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AB - A novel method for mapping a modifier gene that is syntenic to its major gene was used to map a male-sex-limited modifier of the expressivity of the Compact phenotype in the myostatin mutant (MstnCmpt-dl1Abc) Compact mouse. The modifier was mapped to the general region of D1Mit262, 40 cM distal to Mstn on chromosome 1. Myogenin, a postulated downstream target of myostatin, maps to the same region.

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Mapping a syntenic modifier on mouse chromosome 1 influencing the expressivity of the compact phenotype in the myostatin mutant (Mstn ^Cmpt-dl1Abc) compact mouse

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