Mapping Gene Circuits Essential for Germ Layer Differentiation via Loss-of-Function Screens in Haploid Human Embryonic Stem Cells

Keyphrases

• Human Embryonic Stem Cells (hESCs) 100%
• Germ Layers 100%
• Loss-of-function Screen 100%
• Germ Layer Specification 100%
• Gene Circuits 100%
• Human Pluripotent Stem Cells (hPSCs) 66%
• Transcription Factor 33%
• Lineage-specific 33%
• Signaling Pathway 33%
• Microcephaly 33%
• Endoplasmic Reticulum 33%
• Pluripotent Stem Cells 33%
• Loss Function 33%
• Plasma Membrane 33%
• Three Germ Layers 33%
• Cell Fate Transition 33%
• Gastrulation 33%
• Gene Network 33%
• Golgi 33%
• Lineage Differentiation 33%
• Function Library 33%
• Hereditary Neurological Disorders 33%
• Exit from Pluripotency 33%
• Human Remains 33%

Biochemistry, Genetics and Molecular Biology

• Embryonic Stem Cell 100%
• Germ Layer 100%
• Gene Mapping 100%
• Essential Gene 80%
• Stem Cell 60%
• Transcription Factors 20%
• Signal Transduction 20%
• Cell Membrane 20%
• Cell Fate 20%
• Gastrulation 20%
• Gene Network 20%