Mapping the breakome reveals tight regulation on oncogenic super-enhancers

Sara Oster; Rami I. Aqeilan

doi:10.1080/23723556.2019.1698933

Mapping the breakome reveals tight regulation on oncogenic super-enhancers

Sara Oster, Rami I. Aqeilan^*

^*Corresponding author for this work

Department of Immunology and Cancer Research

Research output: Contribution to journal › Comment/debate

3 Scopus citations

Abstract

DNA double-strand breaks (DSBs) could be deleterious and lead to age-related diseases, such as cancer. Recent evidence, however, associates DSBs with vital cellular processes. As discussed here, genome-wide mapping of DSBs revealed an unforeseen coupling mechanism between transcription and DNA repair at super-enhancers, as means of hypertranscription of oncogenic drivers.

Original language	English
Article number	1698933
Journal	Molecular and Cellular Oncology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2019.1698933
State	Published - 3 May 2020

Bibliographical note

Funding Information:
This work was supported by the H2020 European Research Council [682118)].

Publisher Copyright:
© 2020, © 2020 Taylor & Francis Group, LLC.

Keywords

BLISS
DSBs
RAD51
breakome
super-enhancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2019.1698933

Cite this

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abstract = "DNA double-strand breaks (DSBs) could be deleterious and lead to age-related diseases, such as cancer. Recent evidence, however, associates DSBs with vital cellular processes. As discussed here, genome-wide mapping of DSBs revealed an unforeseen coupling mechanism between transcription and DNA repair at super-enhancers, as means of hypertranscription of oncogenic drivers.",

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AB - DNA double-strand breaks (DSBs) could be deleterious and lead to age-related diseases, such as cancer. Recent evidence, however, associates DSBs with vital cellular processes. As discussed here, genome-wide mapping of DSBs revealed an unforeseen coupling mechanism between transcription and DNA repair at super-enhancers, as means of hypertranscription of oncogenic drivers.

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KW - breakome

KW - super-enhancer

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Mapping the breakome reveals tight regulation on oncogenic super-enhancers

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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