Abstract
DNA double-strand breaks (DSBs) could be deleterious and lead to age-related diseases, such as cancer. Recent evidence, however, associates DSBs with vital cellular processes. As discussed here, genome-wide mapping of DSBs revealed an unforeseen coupling mechanism between transcription and DNA repair at super-enhancers, as means of hypertranscription of oncogenic drivers.
Original language | English |
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Article number | 1698933 |
Journal | Molecular and Cellular Oncology |
Volume | 7 |
Issue number | 3 |
DOIs |
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State | Published - 3 May 2020 |
Bibliographical note
Funding Information:This work was supported by the H2020 European Research Council [682118)].
Publisher Copyright:
© 2020, © 2020 Taylor & Francis Group, LLC.
Keywords
- BLISS
- DSBs
- RAD51
- breakome
- super-enhancer