Mapping the breakome reveals tight regulation on oncogenic super-enhancers

Sara Oster, Rami I. Aqeilan*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

DNA double-strand breaks (DSBs) could be deleterious and lead to age-related diseases, such as cancer. Recent evidence, however, associates DSBs with vital cellular processes. As discussed here, genome-wide mapping of DSBs revealed an unforeseen coupling mechanism between transcription and DNA repair at super-enhancers, as means of hypertranscription of oncogenic drivers.

Original languageAmerican English
Article number1698933
JournalMolecular and Cellular Oncology
Volume7
Issue number3
DOIs
StatePublished - 3 May 2020

Bibliographical note

Funding Information:
This work was supported by the H2020 European Research Council [682118)].

Publisher Copyright:
© 2020, © 2020 Taylor & Francis Group, LLC.

Keywords

  • BLISS
  • DSBs
  • RAD51
  • breakome
  • super-enhancer

Fingerprint

Dive into the research topics of 'Mapping the breakome reveals tight regulation on oncogenic super-enhancers'. Together they form a unique fingerprint.

Cite this