Marek's disease vaccines cause temporary B-lymphocyte dysfunction and reduced resistance to infection in chicks

A. Friedman; Edna Shalem-Meilin; E. D. Heller

doi:10.1080/03079459208418883

Marek's disease vaccines cause temporary B-lymphocyte dysfunction and reduced resistance to infection in chicks

A. Friedman, Edna Shalem-Meilin, E. D. Heller

Department of Animal Sciences

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

One-day-old chicks were vaccinated with one of the commercially used vaccines [herpes virus of turkeys (HVT), bivalent HVT+SB1 or Rispens] and the immune response and resistance to infection evaluated. A temporary depletion of B-lymphocyte activity of varying intensity was found, as demonstrated by a diminished response to a B-lymphocyte-specific mitogen in vitro, and by decreased antibody production to BSA in vivo. Of the three vaccines tested, the bivalent vaccine (HVT+SB1) and Rispens were the most damaging. A temporary decreased resistance to pathogenic E coli infection in vaccinated chicks was observed.

Original language	English
Pages (from-to)	621-631
Number of pages	11
Journal	Avian Pathology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1080/03079459208418883
State	Published - 1 Dec 1992

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title = "Marek's disease vaccines cause temporary B-lymphocyte dysfunction and reduced resistance to infection in chicks",

abstract = "One-day-old chicks were vaccinated with one of the commercially used vaccines [herpes virus of turkeys (HVT), bivalent HVT+SB1 or Rispens] and the immune response and resistance to infection evaluated. A temporary depletion of B-lymphocyte activity of varying intensity was found, as demonstrated by a diminished response to a B-lymphocyte-specific mitogen in vitro, and by decreased antibody production to BSA in vivo. Of the three vaccines tested, the bivalent vaccine (HVT+SB1) and Rispens were the most damaging. A temporary decreased resistance to pathogenic E coli infection in vaccinated chicks was observed.",

author = "A. Friedman and Edna Shalem-Meilin and Heller, \{E. D.\}",

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AU - Heller, E. D.

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N2 - One-day-old chicks were vaccinated with one of the commercially used vaccines [herpes virus of turkeys (HVT), bivalent HVT+SB1 or Rispens] and the immune response and resistance to infection evaluated. A temporary depletion of B-lymphocyte activity of varying intensity was found, as demonstrated by a diminished response to a B-lymphocyte-specific mitogen in vitro, and by decreased antibody production to BSA in vivo. Of the three vaccines tested, the bivalent vaccine (HVT+SB1) and Rispens were the most damaging. A temporary decreased resistance to pathogenic E coli infection in vaccinated chicks was observed.

AB - One-day-old chicks were vaccinated with one of the commercially used vaccines [herpes virus of turkeys (HVT), bivalent HVT+SB1 or Rispens] and the immune response and resistance to infection evaluated. A temporary depletion of B-lymphocyte activity of varying intensity was found, as demonstrated by a diminished response to a B-lymphocyte-specific mitogen in vitro, and by decreased antibody production to BSA in vivo. Of the three vaccines tested, the bivalent vaccine (HVT+SB1) and Rispens were the most damaging. A temporary decreased resistance to pathogenic E coli infection in vaccinated chicks was observed.

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Marek's disease vaccines cause temporary B-lymphocyte dysfunction and reduced resistance to infection in chicks

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