Markedly different cytotoxicity of the two enantiomers of C 2-symmetrical Ti(iv) phenolato complexes; Mechanistic implications

Cesar M. Manna; Edit Y. Tshuva

doi:10.1039/b920786b

Markedly different cytotoxicity of the two enantiomers of C ₂-symmetrical Ti(iv) phenolato complexes; Mechanistic implications

Cesar M. Manna, Edit Y. Tshuva

Institute of Chemistry

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29 Scopus citations

Abstract

The two enantiomers of a member of the highly active C₂- symmetrical bis(isopropoxo) Ti(iv) family of complexes of diamine bis(phenolato) ligands demonstrate markedly different cytotoxicity, supporting a chiral biological target of activity and participation of a ligand-bound active species.

Original language	English
Pages (from-to)	1182-1184
Number of pages	3
Journal	Dalton Transactions
Volume	39
Issue number	5
DOIs	https://doi.org/10.1039/b920786b
State	Published - 2010

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abstract = "The two enantiomers of a member of the highly active C2- symmetrical bis(isopropoxo) Ti(iv) family of complexes of diamine bis(phenolato) ligands demonstrate markedly different cytotoxicity, supporting a chiral biological target of activity and participation of a ligand-bound active species.",

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AB - The two enantiomers of a member of the highly active C2- symmetrical bis(isopropoxo) Ti(iv) family of complexes of diamine bis(phenolato) ligands demonstrate markedly different cytotoxicity, supporting a chiral biological target of activity and participation of a ligand-bound active species.

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Markedly different cytotoxicity of the two enantiomers of C ₂-symmetrical Ti(iv) phenolato complexes; Mechanistic implications

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