MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients

On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO)

doi:10.1007/s00520-020-05803-4

MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients

On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO)

ZAMERET

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Objective: The aim of this sub-analysis was to highlight the MASCC/ISOO clinical practice guidelines for the management of oral mucositis (OM) in pediatric patients and to present unique considerations in this patient population. Methods: This sub-analysis of the pediatric patient population is based on the systematic review conducted by the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISSO) published in 2019/2020. Studies were scored and assigned a level of evidence based on previously published criteria. Data regarding adverse effects and compliance was collected from the original publications. Results: A total of 45 papers were included and assessed in this sub-analysis, including 21 randomized controlled trials (RCTs). Chewing gum was demonstrated to be not effective in preventing OM in pediatric cancer patients in 2 RCTs. The efficacy of all other interventions could not be determined based on the available literature. Conclusion: There is limited or conflicting evidence about interventions for the management of OM in pediatric cancer patients, except for chewing gum which was ineffective for prevention. Therefore, currently, data from adult studies may need to be extrapolated for the management of pediatric patients. Honey and photobiomodulation therapy in this patient population had encouraging potential. Implementation of a basic oral care protocol is advised amid lack of high level of evidence studies.

Original language	American English
Pages (from-to)	3539-3562
Number of pages	24
Journal	Supportive Care in Cancer
Volume	29
Issue number	7
DOIs	https://doi.org/10.1007/s00520-020-05803-4
State	Published - Jul 2021

Bibliographical note

Funding Information:
PRA has received grants and personal fees from PhotomedTech, personal fees from Kerber Applied Research, personal fees from Seaborough, personal fees from Shepherd University, non-financial support from National Institute of Aging, NIH, personal fees from Curalaser, personal fees and non-financial support from Vielight, personal fees from Zoovv, non-financial support from Thor Photomedicine, non-financial support from Weber Medical, non-financial support from K laser (Summa), non-financial support from Biolase, non-financial support from Irradia, non-financial support from Quasar Biotech, and non-financial support from Light scalpel, outside the submitted work; In addition, PRA has a patent light-based dental systems issued.

Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

Cancer
Evidence-based
Guidelines
Oral mucositis
Pain
Pediatric patients
Prevention
Treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00520-020-05803-4

Cite this

On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO) (2021). MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients. Supportive Care in Cancer, 29(7), 3539-3562. https://doi.org/10.1007/s00520-020-05803-4

On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO). / MASCC/ISOO clinical practice guidelines for the management of mucositis : sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients. In: Supportive Care in Cancer. 2021 ; Vol. 29, No. 7. pp. 3539-3562.

@article{51e2a1aaae89409b8f2c8cd85440eb7a,

title = "MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients",

abstract = "Objective: The aim of this sub-analysis was to highlight the MASCC/ISOO clinical practice guidelines for the management of oral mucositis (OM) in pediatric patients and to present unique considerations in this patient population. Methods: This sub-analysis of the pediatric patient population is based on the systematic review conducted by the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISSO) published in 2019/2020. Studies were scored and assigned a level of evidence based on previously published criteria. Data regarding adverse effects and compliance was collected from the original publications. Results: A total of 45 papers were included and assessed in this sub-analysis, including 21 randomized controlled trials (RCTs). Chewing gum was demonstrated to be not effective in preventing OM in pediatric cancer patients in 2 RCTs. The efficacy of all other interventions could not be determined based on the available literature. Conclusion: There is limited or conflicting evidence about interventions for the management of OM in pediatric cancer patients, except for chewing gum which was ineffective for prevention. Therefore, currently, data from adult studies may need to be extrapolated for the management of pediatric patients. Honey and photobiomodulation therapy in this patient population had encouraging potential. Implementation of a basic oral care protocol is advised amid lack of high level of evidence studies.",

keywords = "Cancer, Evidence-based, Guidelines, Oral mucositis, Pain, Pediatric patients, Prevention, Treatment",

author = "{On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO)} and Wanessa Miranda-Silva and Wagner Gomes-Silva and Yehuda Zadik and Noam Yarom and Al-Azri, {Abdul Rahman} and Hong, {Catherine H.L.} and Anura Ariyawardana and Saunders, {Deborah P.} and Correa, {M. Elvira} and Arany, {Praveen R.} and Joanne Bowen and Cheng, {Karis Kin Fong} and Tissing, {Wim J.E.} and Paolo Bossi and Sharon Elad",

note = "Funding Information: PRA has received grants and personal fees from PhotomedTech, personal fees from Kerber Applied Research, personal fees from Seaborough, personal fees from Shepherd University, non-financial support from National Institute of Aging, NIH, personal fees from Curalaser, personal fees and non-financial support from Vielight, personal fees from Zoovv, non-financial support from Thor Photomedicine, non-financial support from Weber Medical, non-financial support from K laser (Summa), non-financial support from Biolase, non-financial support from Irradia, non-financial support from Quasar Biotech, and non-financial support from Light scalpel, outside the submitted work; In addition, PRA has a patent light-based dental systems issued. Publisher Copyright: {\textcopyright} 2020, Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2021",

month = jul,

doi = "10.1007/s00520-020-05803-4",

language = "American English",

volume = "29",

pages = "3539--3562",

journal = "Supportive Care in Cancer",

issn = "0941-4355",

publisher = "Springer Verlag",

number = "7",

}

On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO) 2021, 'MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients', Supportive Care in Cancer, vol. 29, no. 7, pp. 3539-3562. https://doi.org/10.1007/s00520-020-05803-4

MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients. / On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO).
In: Supportive Care in Cancer, Vol. 29, No. 7, 07.2021, p. 3539-3562.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - MASCC/ISOO clinical practice guidelines for the management of mucositis

T2 - sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients

AU - On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO)

AU - Miranda-Silva, Wanessa

AU - Gomes-Silva, Wagner

AU - Zadik, Yehuda

AU - Yarom, Noam

AU - Al-Azri, Abdul Rahman

AU - Hong, Catherine H.L.

AU - Ariyawardana, Anura

AU - Saunders, Deborah P.

AU - Correa, M. Elvira

AU - Arany, Praveen R.

AU - Bowen, Joanne

AU - Cheng, Karis Kin Fong

AU - Tissing, Wim J.E.

AU - Bossi, Paolo

AU - Elad, Sharon

N1 - Funding Information: PRA has received grants and personal fees from PhotomedTech, personal fees from Kerber Applied Research, personal fees from Seaborough, personal fees from Shepherd University, non-financial support from National Institute of Aging, NIH, personal fees from Curalaser, personal fees and non-financial support from Vielight, personal fees from Zoovv, non-financial support from Thor Photomedicine, non-financial support from Weber Medical, non-financial support from K laser (Summa), non-financial support from Biolase, non-financial support from Irradia, non-financial support from Quasar Biotech, and non-financial support from Light scalpel, outside the submitted work; In addition, PRA has a patent light-based dental systems issued. Publisher Copyright: © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2021/7

Y1 - 2021/7

N2 - Objective: The aim of this sub-analysis was to highlight the MASCC/ISOO clinical practice guidelines for the management of oral mucositis (OM) in pediatric patients and to present unique considerations in this patient population. Methods: This sub-analysis of the pediatric patient population is based on the systematic review conducted by the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISSO) published in 2019/2020. Studies were scored and assigned a level of evidence based on previously published criteria. Data regarding adverse effects and compliance was collected from the original publications. Results: A total of 45 papers were included and assessed in this sub-analysis, including 21 randomized controlled trials (RCTs). Chewing gum was demonstrated to be not effective in preventing OM in pediatric cancer patients in 2 RCTs. The efficacy of all other interventions could not be determined based on the available literature. Conclusion: There is limited or conflicting evidence about interventions for the management of OM in pediatric cancer patients, except for chewing gum which was ineffective for prevention. Therefore, currently, data from adult studies may need to be extrapolated for the management of pediatric patients. Honey and photobiomodulation therapy in this patient population had encouraging potential. Implementation of a basic oral care protocol is advised amid lack of high level of evidence studies.

AB - Objective: The aim of this sub-analysis was to highlight the MASCC/ISOO clinical practice guidelines for the management of oral mucositis (OM) in pediatric patients and to present unique considerations in this patient population. Methods: This sub-analysis of the pediatric patient population is based on the systematic review conducted by the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISSO) published in 2019/2020. Studies were scored and assigned a level of evidence based on previously published criteria. Data regarding adverse effects and compliance was collected from the original publications. Results: A total of 45 papers were included and assessed in this sub-analysis, including 21 randomized controlled trials (RCTs). Chewing gum was demonstrated to be not effective in preventing OM in pediatric cancer patients in 2 RCTs. The efficacy of all other interventions could not be determined based on the available literature. Conclusion: There is limited or conflicting evidence about interventions for the management of OM in pediatric cancer patients, except for chewing gum which was ineffective for prevention. Therefore, currently, data from adult studies may need to be extrapolated for the management of pediatric patients. Honey and photobiomodulation therapy in this patient population had encouraging potential. Implementation of a basic oral care protocol is advised amid lack of high level of evidence studies.

KW - Cancer

KW - Evidence-based

KW - Guidelines

KW - Oral mucositis

KW - Pain

KW - Pediatric patients

KW - Prevention

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85095687845&partnerID=8YFLogxK

U2 - 10.1007/s00520-020-05803-4

DO - 10.1007/s00520-020-05803-4

M3 - Article

C2 - 33156403

AN - SCOPUS:85095687845

SN - 0941-4355

VL - 29

SP - 3539

EP - 3562

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

IS - 7

ER -

On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO). MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients. Supportive Care in Cancer. 2021 Jul;29(7):3539-3562. doi: 10.1007/s00520-020-05803-4

MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this