Mass action kinetics of virus-cell aggregation and fusion

J. Bentz; S. Nir; D. G. Covell

doi:10.1016/S0006-3495(88)82978-3

Mass action kinetics of virus-cell aggregation and fusion

J. Bentz^*, S. Nir, D. G. Covell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A simple approximate solution for the mass action kinetics of small particles (viruses or vesicles) binding to large particles (cells) and their subsequent fusion has been derived. The solution is evaluated in terms of the measurable fluorescence changes expected when the virus or vesicles are labeled with fluorescent probes, which are diluted into the cellular membrane by fusion. Comparison with numerical integrations shows that the approximate solution is extremely accurate. Analytic simplifications for a variety of special cases of this general problem are also shown.

Original language	English
Pages (from-to)	449-462
Number of pages	14
Journal	Biophysical Journal
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/S0006-3495(88)82978-3
State	Published - 1988
Externally published	Yes

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10.1016/S0006-3495(88)82978-3

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Mass action kinetics of virus-cell aggregation and fusion

Abstract

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