Mass informatics: From mass spectrometry peaks to biological pathways

Manor Askenazi, Michal Linial*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


In this review we will introduce the field of mass informatics, a branch of bioinformatics concerned with the analysis of data from mass spectrometry. As we shall demonstrate, this short definition hides a surprisingly diverse and challenging topic, driven by the remarkable versatility of the mass spectrometer. We first introduce the essential properties of the mass spectrum and highlight its key differences from the more common data types in high-throughput bioinformatics (sequence, microarray and image data). We then explore the breadth of biochemistry accessible through the associated algorithmic challenge of spectral identification. Finally, we demonstrate instances where data-mining techniques can be applied to large-scale spectral libraries, thereby extracting latent biological insight.

Original languageAmerican English
Pages (from-to)157-165
Number of pages9
JournalIsrael Journal of Chemistry
Issue number3-4
StatePublished - Apr 2013


  • bioinformatics
  • bottom-up proteomics
  • data mining
  • mass spectrometry
  • spectral libraries


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