Mast cell stabilizing properties of antihistamines

Francesca Levi-Schaffer*, Ron Eliashar

*Corresponding author for this work

Research output: Contribution to journalComment/debate

27 Scopus citations

Abstract

Histamine is a key mediator of allergic inflammation, primarily through competitive antagonism of binding to H1 receptors. In this issue, Weller and Maurer report that the H1 antagonist desloratadine possesses mast cell-stabilizing properties when challenged in an IgE-dependent or-independent fashion. Thus, desloratadine provides benefits that are independent of H1 receptor binding and based on mast cell stabilization.

Original languageAmerican English
Pages (from-to)2549-2551
Number of pages3
JournalJournal of Investigative Dermatology
Volume129
Issue number11
DOIs
StatePublished - Nov 2009

Bibliographical note

Funding Information:
F. Levi-Schaffer is the recipient of grant funds from the Aimwell Charitable Trust (UK), the Israel Science Foundation, and the Israel Ministry of Health. Dr Levi-Schaffer is a member of the David R Bloom Center for Pharmacy and the Dr Adolph and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics in the School of Pharmacy, the Hebrew University of Jerusalem.

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