Mast cells and eosinophils: A novel link between inflammation and angiogenesis in allergic diseases

Ilaria Puxeddu; Domenico Ribatti; Enrico Crivellato; Francesca Levi-Schaffer

doi:10.1016/j.jaci.2005.06.007

Mast cells and eosinophils: A novel link between inflammation and angiogenesis in allergic diseases

Ilaria Puxeddu, Domenico Ribatti, Enrico Crivellato, Francesca Levi-Schaffer^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

Mast cells and eosinophils are the key cells in the early and late stages of allergic inflammation. There is increasing evidence that angiogenesis plays an important role both in the development of inflammation and in the pathophysiology of tissue remodeling during allergic disorders. In this review we provide recent data showing a link between allergy and angiogenesis and some possible mechanisms through which vascular endothelial growth factor and the immune system can interact. We discuss the multifaceted roles of mast cells and eosinophils in tissue remodeling and angiogenesis during allergic diseases and whether these cells can be both source and target cells for proangiogenic mediators.

Original language	English
Pages (from-to)	531-536
Number of pages	6
Journal	Journal of Allergy and Clinical Immunology
Volume	116
Issue number	3
DOIs	https://doi.org/10.1016/j.jaci.2005.06.007
State	Published - Sep 2005

Bibliographical note

Funding Information:
Supported by a grant from the Aimwell Charitable Trust (London, United Kingdom; FLS) and from the Fondazione Italiana per la Lotta al Neuroblastoma (Genoa, Italy; DR).

Keywords

Allergy
Angiogenesis
Asthma
Eosinophils
Mast cells
Tissue remodeling
Vascular endothelial growth factor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaci.2005.06.007

Cite this

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title = "Mast cells and eosinophils: A novel link between inflammation and angiogenesis in allergic diseases",

abstract = "Mast cells and eosinophils are the key cells in the early and late stages of allergic inflammation. There is increasing evidence that angiogenesis plays an important role both in the development of inflammation and in the pathophysiology of tissue remodeling during allergic disorders. In this review we provide recent data showing a link between allergy and angiogenesis and some possible mechanisms through which vascular endothelial growth factor and the immune system can interact. We discuss the multifaceted roles of mast cells and eosinophils in tissue remodeling and angiogenesis during allergic diseases and whether these cells can be both source and target cells for proangiogenic mediators.",

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AU - Ribatti, Domenico

AU - Crivellato, Enrico

AU - Levi-Schaffer, Francesca

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AB - Mast cells and eosinophils are the key cells in the early and late stages of allergic inflammation. There is increasing evidence that angiogenesis plays an important role both in the development of inflammation and in the pathophysiology of tissue remodeling during allergic disorders. In this review we provide recent data showing a link between allergy and angiogenesis and some possible mechanisms through which vascular endothelial growth factor and the immune system can interact. We discuss the multifaceted roles of mast cells and eosinophils in tissue remodeling and angiogenesis during allergic diseases and whether these cells can be both source and target cells for proangiogenic mediators.

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KW - Angiogenesis

KW - Asthma

KW - Eosinophils

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KW - Tissue remodeling

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Mast cells and eosinophils: A novel link between inflammation and angiogenesis in allergic diseases

Abstract

Bibliographical note

Keywords

UN SDGs

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