Mast cells and eosinophils: A novel link between inflammation and angiogenesis in allergic diseases

Ilaria Puxeddu, Domenico Ribatti, Enrico Crivellato, Francesca Levi-Schaffer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

137 Scopus citations

Abstract

Mast cells and eosinophils are the key cells in the early and late stages of allergic inflammation. There is increasing evidence that angiogenesis plays an important role both in the development of inflammation and in the pathophysiology of tissue remodeling during allergic disorders. In this review we provide recent data showing a link between allergy and angiogenesis and some possible mechanisms through which vascular endothelial growth factor and the immune system can interact. We discuss the multifaceted roles of mast cells and eosinophils in tissue remodeling and angiogenesis during allergic diseases and whether these cells can be both source and target cells for proangiogenic mediators.

Original languageAmerican English
Pages (from-to)531-536
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Volume116
Issue number3
DOIs
StatePublished - Sep 2005

Bibliographical note

Funding Information:
Supported by a grant from the Aimwell Charitable Trust (London, United Kingdom; FLS) and from the Fondazione Italiana per la Lotta al Neuroblastoma (Genoa, Italy; DR).

Keywords

  • Allergy
  • Angiogenesis
  • Asthma
  • Eosinophils
  • Mast cells
  • Tissue remodeling
  • Vascular endothelial growth factor

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