Abstract
Mast cells and eosinophils are the key cells in the early and late stages of allergic inflammation. There is increasing evidence that angiogenesis plays an important role both in the development of inflammation and in the pathophysiology of tissue remodeling during allergic disorders. In this review we provide recent data showing a link between allergy and angiogenesis and some possible mechanisms through which vascular endothelial growth factor and the immune system can interact. We discuss the multifaceted roles of mast cells and eosinophils in tissue remodeling and angiogenesis during allergic diseases and whether these cells can be both source and target cells for proangiogenic mediators.
| Original language | English |
|---|---|
| Pages (from-to) | 531-536 |
| Number of pages | 6 |
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 116 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2005 |
Bibliographical note
Funding Information:Supported by a grant from the Aimwell Charitable Trust (London, United Kingdom; FLS) and from the Fondazione Italiana per la Lotta al Neuroblastoma (Genoa, Italy; DR).
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Allergy
- Angiogenesis
- Asthma
- Eosinophils
- Mast cells
- Tissue remodeling
- Vascular endothelial growth factor
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