Mast Cells' integrated actions with eosinophils and fibroblasts in allergic inflammation: Implications for therapy

Nadine Landolina, Roopesh Singh Gangwar, Francesca Levi-Schaffer*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

32 Scopus citations


Mast cells (MCs) and eosinophils (Eos) are the key players in the development of allergic inflammation (AI). Their cross-talk, named the Allergic Effector Unit (AEU), takes place through an array of soluble mediators and ligands/receptors interactions that enhance the functions of both the cells. One of the salient features of the AEU is the CD48/2B4 receptor/ligand binding complex. Furthermore, MCs and Eos have been demonstrated to play a role not only in AI but also in the modulation of its consequence, i.e., fibrosis/tissue remodeling, by directly influencing fibroblasts (FBs), the main target cells of these processes. In turn, FBs can regulate the survival, activity, and phenotype of both MCs and Eos. Therefore, a complex three players, MCs/Eos/FBs interaction, can take place in various stages of AI. The characterization of the soluble and physical mediated cross talk among these three cells might lead to the identification of both better and novel targets for the treatment of allergy and its tissue remodeling consequences.

Original languageAmerican English
Title of host publicationAdvances in Immunology
PublisherAcademic Press Inc.
Number of pages45
StatePublished - 2015

Publication series

NameAdvances in Immunology
ISSN (Print)0065-2776
ISSN (Electronic)1557-8445

Bibliographical note

Funding Information:
F. L.-S. acknowledges grant support from a “Kamin” grant of the Israel Ministry of Industry (File no. 46223), the Israel Science Foundation (Grant 699/10), MAARS EU 7th framework (Grant No. HEALTH-F2-2011-261366), and the Aimwell Charitable Trust Foundation (UK). F. L.-S. is a member of the Dr. Adolph and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics, and the David R. Bloom Center for Pharmacy at The Hebrew University of Jerusalem's School of Pharmacy. We wish to thank Madelyn Segev for her secretarial and editing assistance.

Publisher Copyright:
© 2015 Elsevier Inc.


  • Allergic Effector Unit
  • Allergic inflammation
  • Asthma
  • Eosinophils
  • Fibroblast
  • Fibrosis
  • Interaction
  • Mast cells


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