Mast Cells' integrated actions with eosinophils and fibroblasts in allergic inflammation: Implications for therapy

Nadine Landolina, Roopesh Singh Gangwar, Francesca Levi-Schaffer*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

34 Scopus citations

Abstract

Mast cells (MCs) and eosinophils (Eos) are the key players in the development of allergic inflammation (AI). Their cross-talk, named the Allergic Effector Unit (AEU), takes place through an array of soluble mediators and ligands/receptors interactions that enhance the functions of both the cells. One of the salient features of the AEU is the CD48/2B4 receptor/ligand binding complex. Furthermore, MCs and Eos have been demonstrated to play a role not only in AI but also in the modulation of its consequence, i.e., fibrosis/tissue remodeling, by directly influencing fibroblasts (FBs), the main target cells of these processes. In turn, FBs can regulate the survival, activity, and phenotype of both MCs and Eos. Therefore, a complex three players, MCs/Eos/FBs interaction, can take place in various stages of AI. The characterization of the soluble and physical mediated cross talk among these three cells might lead to the identification of both better and novel targets for the treatment of allergy and its tissue remodeling consequences.

Original languageAmerican English
Title of host publicationAdvances in Immunology
PublisherAcademic Press Inc.
Pages41-85
Number of pages45
Edition1
DOIs
StatePublished - 2015

Publication series

NameAdvances in Immunology
Number1
Volume125
ISSN (Print)0065-2776
ISSN (Electronic)1557-8445

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

  • Allergic Effector Unit
  • Allergic inflammation
  • Asthma
  • Eosinophils
  • Fibroblast
  • Fibrosis
  • Interaction
  • Mast cells

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