TY - JOUR
T1 - Maternal plasma concentration of the pro-inflammatory adipokine pre-B-cell-enhancing factor (PBEF)/visfatin is elevated in pregnant patients with acute pyelonephritis
AU - Mazaki-Tovi, Shali
AU - Vaisbuch, Edi
AU - Romero, Roberto
AU - Kusanovic, Juan Pedro
AU - Chaiworapongsa, Tinnakorn
AU - Kim, Sun Kwon
AU - Nhan-Chang, Chia Ling
AU - Gomez, Ricardo
AU - Yoon, Bo H.
AU - Yeo, Lami
AU - Mittal, Pooja
AU - Ogge, Giovanna
AU - Gonzalez, Juan M.
AU - Hassan, Sonia S.
PY - 2010/3
Y1 - 2010/3
N2 - Problem: Visfatin/pre-B-cell-enhancing factor (PBEF) has been implicated in the regulation of the innate immune system, as well as in glucose metabolism. Specifically, visfatin plays a requisite role in delayed neutrophil apoptosis in patients with sepsis. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma visfatin concentration in normal weight and overweight/obese patients. Method of study: This cross-sectional study included the following groups: (1) normal pregnant women (n = 200) and (2) pregnant women with pyelonephritis (n = 40). Maternal plasma visfatin concentrations were determined by ELISA. Non-parametric statistics was used for analyses. Results: (1) The median maternal plasma visfatin concentration was significantly higher in patients with pyelonephritis than in those with a normal pregnancy; (2) among overweight/obese pregnant women, those with pyelonephritis had a significantly higher median plasma visfatin concentration than women with a normal pregnancy; and (3) pyelonephritis was independently associated with higher maternal plasma visfatin concentrations after adjustment for maternal age, pre-gestational body mass index, smoking status, gestational age at sampling, and birthweight. Conclusion: Acute pyelonephritis during pregnancy is associated with a high circulating maternal visfatin concentration. These findings suggest that visfatin/PBEF may play a role in the regulation of the complex and dynamic crosstalk between inflammation and metabolism during pregnancy.
AB - Problem: Visfatin/pre-B-cell-enhancing factor (PBEF) has been implicated in the regulation of the innate immune system, as well as in glucose metabolism. Specifically, visfatin plays a requisite role in delayed neutrophil apoptosis in patients with sepsis. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma visfatin concentration in normal weight and overweight/obese patients. Method of study: This cross-sectional study included the following groups: (1) normal pregnant women (n = 200) and (2) pregnant women with pyelonephritis (n = 40). Maternal plasma visfatin concentrations were determined by ELISA. Non-parametric statistics was used for analyses. Results: (1) The median maternal plasma visfatin concentration was significantly higher in patients with pyelonephritis than in those with a normal pregnancy; (2) among overweight/obese pregnant women, those with pyelonephritis had a significantly higher median plasma visfatin concentration than women with a normal pregnancy; and (3) pyelonephritis was independently associated with higher maternal plasma visfatin concentrations after adjustment for maternal age, pre-gestational body mass index, smoking status, gestational age at sampling, and birthweight. Conclusion: Acute pyelonephritis during pregnancy is associated with a high circulating maternal visfatin concentration. These findings suggest that visfatin/PBEF may play a role in the regulation of the complex and dynamic crosstalk between inflammation and metabolism during pregnancy.
KW - Acute bacterial infection
KW - Adipokines
KW - BMI
KW - Cytokine
KW - Infection
KW - Inflammation
KW - Maternal obesity
KW - Overweight
KW - Pregnancy
KW - Urinary tract infection
UR - http://www.scopus.com/inward/record.url?scp=76549100382&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.2009.00804.x
DO - 10.1111/j.1600-0897.2009.00804.x
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C2 - 20085562
AN - SCOPUS:76549100382
SN - 1046-7408
VL - 63
SP - 252
EP - 262
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 3
ER -