Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia

J. Bah; H. Quach; R. P. Ebstein; R. H. Segman; J. Melke; S. Jamain; M. Rietschel; I. Modai; K. Kanas; O. Karni; B. Lerer; D. Gourion; M. O. Krebs; B. Etain; F. Schürhoff; A. Szöke; M. Leboyer; T. Bourgeron

doi:10.1097/00001756-200408260-00031

Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia

J. Bah
, H. Quach
, R. P. Ebstein
, R. H. Segman
, J. Melke
, S. Jamain
, M. Rietschel
, I. Modai
, K. Kanas
, O. Karni
, B. Lerer
, D. Gourion
, M. O. Krebs
, B. Etain
, F. Schürhoff
, A. Szöke
, M. Leboyer
, T. Bourgeron^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Schizophrenia is characterized by thought disorders, hallucinations and delusions. Genetic studies have shown a high linkage at chromosome 6q16-21. Among the genes located in this region is the glutamate receptor ionotropic kainate 2 gene (GRIK2 or GLUR6), a functional candidate for susceptibility to schizophrenia. In this study, transmission of GRIK2 was evaluated in 356 schizophrenic patients from three different clinical centers. Whereas paternal transmission shows equilibrium, we observed maternal transmission disequilibrium of GRIK2 in the largest population (p=0.03), which was still significant when all populations were added (p=0.05). These results are similar to the maternal GRIK2 transmission disequilibrium previously reported for autism, and support the presence of a susceptibility gene for schizophrenia at 6q16.

Original language	English
Pages (from-to)	1987-1991
Number of pages	5
Journal	NeuroReport
Volume	15
Issue number	12
DOIs	https://doi.org/10.1097/00001756-200408260-00031
State	Published - 26 Aug 2004
Externally published	Yes

Keywords

Chromosome 6q
Glutamate
Imprinting
Kainate
Polymorphism
Schizophrenia

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10.1097/00001756-200408260-00031

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Bah, J., Quach, H., Ebstein, R. P., Segman, R. H., Melke, J., Jamain, S., Rietschel, M., Modai, I., Kanas, K., Karni, O., Lerer, B., Gourion, D., Krebs, M. O., Etain, B., Schürhoff, F., Szöke, A., Leboyer, M., & Bourgeron, T. (2004). Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia. NeuroReport, 15(12), 1987-1991. https://doi.org/10.1097/00001756-200408260-00031

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title = "Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia",

abstract = "Schizophrenia is characterized by thought disorders, hallucinations and delusions. Genetic studies have shown a high linkage at chromosome 6q16-21. Among the genes located in this region is the glutamate receptor ionotropic kainate 2 gene (GRIK2 or GLUR6), a functional candidate for susceptibility to schizophrenia. In this study, transmission of GRIK2 was evaluated in 356 schizophrenic patients from three different clinical centers. Whereas paternal transmission shows equilibrium, we observed maternal transmission disequilibrium of GRIK2 in the largest population (p=0.03), which was still significant when all populations were added (p=0.05). These results are similar to the maternal GRIK2 transmission disequilibrium previously reported for autism, and support the presence of a susceptibility gene for schizophrenia at 6q16.",

keywords = "Chromosome 6q, Glutamate, Imprinting, Kainate, Polymorphism, Schizophrenia",

author = "J. Bah and H. Quach and Ebstein, \{R. P.\} and Segman, \{R. H.\} and J. Melke and S. Jamain and M. Rietschel and I. Modai and K. Kanas and O. Karni and B. Lerer and D. Gourion and Krebs, \{M. O.\} and B. Etain and F. Sch{\"u}rhoff and A. Sz{\"o}ke and M. Leboyer and T. Bourgeron",

year = "2004",

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doi = "10.1097/00001756-200408260-00031",

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Bah, J, Quach, H, Ebstein, RP, Segman, RH, Melke, J, Jamain, S, Rietschel, M, Modai, I, Kanas, K, Karni, O, Lerer, B, Gourion, D, Krebs, MO, Etain, B, Schürhoff, F, Szöke, A, Leboyer, M & Bourgeron, T 2004, 'Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia', NeuroReport, vol. 15, no. 12, pp. 1987-1991. https://doi.org/10.1097/00001756-200408260-00031

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T1 - Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia

AU - Bah, J.

AU - Quach, H.

AU - Ebstein, R. P.

AU - Segman, R. H.

AU - Melke, J.

AU - Jamain, S.

AU - Rietschel, M.

AU - Modai, I.

AU - Kanas, K.

AU - Karni, O.

AU - Lerer, B.

AU - Gourion, D.

AU - Krebs, M. O.

AU - Etain, B.

AU - Schürhoff, F.

AU - Szöke, A.

AU - Leboyer, M.

AU - Bourgeron, T.

PY - 2004/8/26

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N2 - Schizophrenia is characterized by thought disorders, hallucinations and delusions. Genetic studies have shown a high linkage at chromosome 6q16-21. Among the genes located in this region is the glutamate receptor ionotropic kainate 2 gene (GRIK2 or GLUR6), a functional candidate for susceptibility to schizophrenia. In this study, transmission of GRIK2 was evaluated in 356 schizophrenic patients from three different clinical centers. Whereas paternal transmission shows equilibrium, we observed maternal transmission disequilibrium of GRIK2 in the largest population (p=0.03), which was still significant when all populations were added (p=0.05). These results are similar to the maternal GRIK2 transmission disequilibrium previously reported for autism, and support the presence of a susceptibility gene for schizophrenia at 6q16.

AB - Schizophrenia is characterized by thought disorders, hallucinations and delusions. Genetic studies have shown a high linkage at chromosome 6q16-21. Among the genes located in this region is the glutamate receptor ionotropic kainate 2 gene (GRIK2 or GLUR6), a functional candidate for susceptibility to schizophrenia. In this study, transmission of GRIK2 was evaluated in 356 schizophrenic patients from three different clinical centers. Whereas paternal transmission shows equilibrium, we observed maternal transmission disequilibrium of GRIK2 in the largest population (p=0.03), which was still significant when all populations were added (p=0.05). These results are similar to the maternal GRIK2 transmission disequilibrium previously reported for autism, and support the presence of a susceptibility gene for schizophrenia at 6q16.

KW - Chromosome 6q

KW - Glutamate

KW - Imprinting

KW - Kainate

KW - Polymorphism

KW - Schizophrenia

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SN - 0959-4965

VL - 15

SP - 1987

EP - 1991

JO - NeuroReport

JF - NeuroReport

IS - 12

ER -

Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia

Abstract

Keywords

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