TY - JOUR
T1 - Math 1
T2 - An essential gene for the generation of inner ear hair cells
AU - Bermingham, Nessan A.
AU - Hassan, Bassem A.
AU - Price, Steven D.
AU - Vollrath, Melissa A.
AU - Ben-Arie, Nissim
AU - Eatock, Ruth Anne
AU - Bellen, Hugo J.
AU - Lysakowski, Anna
AU - Zoghbi, Huda Y.
PY - 1999/6/11
Y1 - 1999/6/11
N2 - The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. Math 1, a mouse homolog of the Drosophila proneural gene atonal, is expressed in inner ear sensory epithelia. Embryonic Math 1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells.
AB - The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. Math 1, a mouse homolog of the Drosophila proneural gene atonal, is expressed in inner ear sensory epithelia. Embryonic Math 1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells.
UR - http://www.scopus.com/inward/record.url?scp=0033546004&partnerID=8YFLogxK
U2 - 10.1126/science.284.5421.1837
DO - 10.1126/science.284.5421.1837
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 10364557
AN - SCOPUS:0033546004
SN - 0036-8075
VL - 284
SP - 1837
EP - 1841
JO - Science
JF - Science
IS - 5421
ER -