Math 1: An essential gene for the generation of inner ear hair cells

Nessan A. Bermingham, Bassem A. Hassan, Steven D. Price, Melissa A. Vollrath, Nissim Ben-Arie, Ruth Anne Eatock, Hugo J. Bellen, Anna Lysakowski, Huda Y. Zoghbi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

926 Scopus citations

Abstract

The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. Math 1, a mouse homolog of the Drosophila proneural gene atonal, is expressed in inner ear sensory epithelia. Embryonic Math 1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells.

Original languageAmerican English
Pages (from-to)1837-1841
Number of pages5
JournalScience
Volume284
Issue number5421
DOIs
StatePublished - 11 Jun 1999

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