Matrices of acidic β-sheet peptides as templates for calcium phosphate mineralization

Shlomit Segman-Magidovich*, Haviv Grisaru, Tamar Gitli, Yael Levi-Kalisman, Hanna Rapaport

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Early stage of calcium phosphate mineralization on designed β-sheet peptides was monitored that may serve as nucleating templates for hydroxyapatite. A solution composed of the various ions present in the blood serum, in 1.5× their physiological concentration, was selected to monitor the mineralization under conditions that may be of biological relevancy. A film of the peptide that is spread on SBF1.5 and held 18 hrs in the expanded state prior to compression, becomes less compressible. The TEM images showed structural features that are nanomeric in scale, and found that the flat calcium phosphate sheets could be a form of unchanged amorphous calcium phosphate aggregates. The 20 days mineralized peptide film shows the most prominent differences between the 20 days and 10 days spectra with an enhanced absorption at 1037 cm-1.

Original languageAmerican English
Pages (from-to)2156-2161
Number of pages6
JournalAdvanced Materials
Issue number11
StatePublished - 4 Jun 2008
Externally publishedYes


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