TY - JOUR
T1 - mazEF
T2 - A chromosomal toxin-antitoxin module that triggers programmed cell death in bacteria
AU - Engelberg-Kulka, Hanna
AU - Hazan, Ronen
AU - Amitai, Shahar
PY - 2005/10/1
Y1 - 2005/10/1
N2 - mazEF is a toxin-antitoxin module located on the Escherichia coli chromosome and that of some other bacteria, including pathogens. mazF specifies for a stable toxin, MazF, and mazE specifies for a labile antitoxin, MazE, that antagonizes MazF. MazF is a sequence-specific mRNA endoribonuclease that initiates a programmed cell death pathway in response to various stresses. The mazEF-mediated death pathway can act as a defense mechanism that prevents the spread of bacterial phage infection, allowing bacterial populations to behave like multicellular organisms.
AB - mazEF is a toxin-antitoxin module located on the Escherichia coli chromosome and that of some other bacteria, including pathogens. mazF specifies for a stable toxin, MazF, and mazE specifies for a labile antitoxin, MazE, that antagonizes MazF. MazF is a sequence-specific mRNA endoribonuclease that initiates a programmed cell death pathway in response to various stresses. The mazEF-mediated death pathway can act as a defense mechanism that prevents the spread of bacterial phage infection, allowing bacterial populations to behave like multicellular organisms.
KW - Bacterial toxin-antitoxins
KW - Programmed cell death
KW - Stressful conditions
UR - http://www.scopus.com/inward/record.url?scp=27644590965&partnerID=8YFLogxK
U2 - 10.1242/jcs.02619
DO - 10.1242/jcs.02619
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C2 - 16179604
AN - SCOPUS:27644590965
SN - 0021-9533
VL - 118
SP - 4327
EP - 4332
JO - Journal of Cell Science
JF - Journal of Cell Science
IS - 19
ER -