Measuring pupil size and light response through closed eyelids

Yousef Farraj, Amnon Buxboim, Jose E. Cohen, Yoav Kan-Tor, Shira Glasner Hagege, Dor Weiss, Vladimir Goldman, Tsevi Beatus*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Monitoring pupillary size and light-reactivity is a key component of the neurologic assessment in comatose patients after stroke or brain trauma. Currently, pupillary evaluation is performed manually at a frequency often too low to ensure timely alert for irreversible brain damage. We present a novel method for monitoring pupillary size and reactivity through closed eyelids. Our method is based on side illuminating in near-IR through the temple and imaging through the closed eyelid. Successfully tested in a clinical trial, this technology can be implemented as an automated device for continuous pupillary monitoring, which may save staff resources and provide earlier alert to potential brain damage in comatose patients.

Original languageAmerican English
Pages (from-to)6485-6495
Number of pages11
JournalBiomedical Optics Express
Issue number10
StatePublished - 1 Oct 2021

Bibliographical note

Publisher Copyright:
© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement


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