TY - JOUR
T1 - Mechanical injury increases eicosanoid production in cultured cardiomyocytes
AU - Pinson, A.
AU - Halabi, A.
AU - Shohami, E.
PY - 1992/5
Y1 - 1992/5
N2 - The release of three stable metabolites of the arachidonic acid cascade was determined in cultures of cardiac myocytes and of non-muscle cells. In both cell types, the main product was 6-keto-PGF1α much less PGE2 was released, while TXB2 was only detected in muscle cells. Preincubation with arachidonic acid increased the release of all the PGs in both types of culture. Mechanical injury had a synergistic effect on the increased PG release in AA-preincubated cells. However, TXB2 was not detected in F-cells in any experimental conditions. These results suggest that PG production serves a functional role in heart preservation during injury.
AB - The release of three stable metabolites of the arachidonic acid cascade was determined in cultures of cardiac myocytes and of non-muscle cells. In both cell types, the main product was 6-keto-PGF1α much less PGE2 was released, while TXB2 was only detected in muscle cells. Preincubation with arachidonic acid increased the release of all the PGs in both types of culture. Mechanical injury had a synergistic effect on the increased PG release in AA-preincubated cells. However, TXB2 was not detected in F-cells in any experimental conditions. These results suggest that PG production serves a functional role in heart preservation during injury.
UR - http://www.scopus.com/inward/record.url?scp=0026582524&partnerID=8YFLogxK
U2 - 10.1016/0952-3278(92)90052-K
DO - 10.1016/0952-3278(92)90052-K
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 1631177
AN - SCOPUS:0026582524
SN - 0952-3278
VL - 46
SP - 9
EP - 13
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 1
ER -