TY - JOUR
T1 - Mechanical properties and histology of charge modified bioprosthetic tissue resistant to calcification
AU - Golomb, Gershon
AU - Lewinstein, Israel
AU - Ezra, Vittoria
AU - Schoen, Frederick J.
PY - 1992
Y1 - 1992
N2 - Modification of bioprosthetic heart valves tissue by covalently binding protamine sulphate, results in stable covalent links of protamine to the tissue, conferring resistance to calcification. We report here the morphological evaluation and mechanical properties (elastic modulus and ultimate tensile strength) of protamine-bound bioprosthetic tissues that have high anticalcification potential. Protamine-bound bioprosthetic tissue had significantly higher tissue modulus and ultimate tensile strength values than control tissue groups. However, the mechanical properties and tissue architecture were inferior to those of bioprosthetic tissue.
AB - Modification of bioprosthetic heart valves tissue by covalently binding protamine sulphate, results in stable covalent links of protamine to the tissue, conferring resistance to calcification. We report here the morphological evaluation and mechanical properties (elastic modulus and ultimate tensile strength) of protamine-bound bioprosthetic tissues that have high anticalcification potential. Protamine-bound bioprosthetic tissue had significantly higher tissue modulus and ultimate tensile strength values than control tissue groups. However, the mechanical properties and tissue architecture were inferior to those of bioprosthetic tissue.
KW - Calcification
KW - heart valve prostheses
KW - mechanical properties
KW - surface modification
UR - http://www.scopus.com/inward/record.url?scp=0026573356&partnerID=8YFLogxK
U2 - 10.1016/0142-9612(92)90039-Q
DO - 10.1016/0142-9612(92)90039-Q
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C2 - 1610958
AN - SCOPUS:0026573356
SN - 0142-9612
VL - 13
SP - 353
EP - 356
JO - Biomaterials
JF - Biomaterials
IS - 6
ER -