Mechanism and reaction products of the oxidation of CU(I)-phenanthroline by H2O2

Sara Goldstein; Gidon Czapski

doi:10.1016/0748-5514(85)90149-7

Mechanism and reaction products of the oxidation of CU(I)-phenanthroline by H₂O₂

Sara Goldstein, Gidon Czapski^*

^*Corresponding author for this work

School of Nursing

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We have suggested a possible reaction mechanism for the oxidation of the corpus phenanthroline complex by H₂O₂ in the presence of formate and methanol. The cuprous phenanthroline complex was generated by pulse and γ radiolysis. We measured the decay kinetics of this complex as well as the chain length of this reaction. Our observations indicate that in this reaction OH· is not formed directly, but through the decomposition of a metal-peroxo complex. This mechanism does not necessarily operate with other copper compounds, especially with copper complexes bound to a biological target.

Original language	English
Pages (from-to)	373-380
Number of pages	8
Journal	Journal of Free Radicals in Biology and Medicine
Volume	1
Issue number	5-6
DOIs	https://doi.org/10.1016/0748-5514(85)90149-7
State	Published - 1985

Keywords

Chain length
Copper phenanthroline
Hydrogen peroxide
Hydroxyl radical
Metal-peroxo complex
Radiolysis

Access to Document

10.1016/0748-5514(85)90149-7

Cite this

@article{560087f5fa3b47d9812815080dffe422,

title = "Mechanism and reaction products of the oxidation of CU(I)-phenanthroline by H2O2",

abstract = "We have suggested a possible reaction mechanism for the oxidation of the corpus phenanthroline complex by H2O2 in the presence of formate and methanol. The cuprous phenanthroline complex was generated by pulse and γ radiolysis. We measured the decay kinetics of this complex as well as the chain length of this reaction. Our observations indicate that in this reaction OH· is not formed directly, but through the decomposition of a metal-peroxo complex. This mechanism does not necessarily operate with other copper compounds, especially with copper complexes bound to a biological target.",

keywords = "Chain length, Copper phenanthroline, Hydrogen peroxide, Hydroxyl radical, Metal-peroxo complex, Radiolysis",

author = "Sara Goldstein and Gidon Czapski",

year = "1985",

doi = "10.1016/0748-5514(85)90149-7",

language = "אנגלית",

volume = "1",

pages = "373--380",

journal = "Journal of Free Radicals in Biology and Medicine",

issn = "0748-5514",

publisher = "Pergamon Press Ltd.",

number = "5-6",

}

TY - JOUR

T1 - Mechanism and reaction products of the oxidation of CU(I)-phenanthroline by H2O2

AU - Goldstein, Sara

AU - Czapski, Gidon

PY - 1985

Y1 - 1985

N2 - We have suggested a possible reaction mechanism for the oxidation of the corpus phenanthroline complex by H2O2 in the presence of formate and methanol. The cuprous phenanthroline complex was generated by pulse and γ radiolysis. We measured the decay kinetics of this complex as well as the chain length of this reaction. Our observations indicate that in this reaction OH· is not formed directly, but through the decomposition of a metal-peroxo complex. This mechanism does not necessarily operate with other copper compounds, especially with copper complexes bound to a biological target.

AB - We have suggested a possible reaction mechanism for the oxidation of the corpus phenanthroline complex by H2O2 in the presence of formate and methanol. The cuprous phenanthroline complex was generated by pulse and γ radiolysis. We measured the decay kinetics of this complex as well as the chain length of this reaction. Our observations indicate that in this reaction OH· is not formed directly, but through the decomposition of a metal-peroxo complex. This mechanism does not necessarily operate with other copper compounds, especially with copper complexes bound to a biological target.

KW - Chain length

KW - Copper phenanthroline

KW - Hydrogen peroxide

KW - Hydroxyl radical

KW - Metal-peroxo complex

KW - Radiolysis

UR - http://www.scopus.com/inward/record.url?scp=0022316880&partnerID=8YFLogxK

U2 - 10.1016/0748-5514(85)90149-7

DO - 10.1016/0748-5514(85)90149-7

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 3837803

AN - SCOPUS:0022316880

SN - 0748-5514

VL - 1

SP - 373

EP - 380

JO - Journal of Free Radicals in Biology and Medicine

JF - Journal of Free Radicals in Biology and Medicine

IS - 5-6

ER -

Mechanism and reaction products of the oxidation of CU(I)-phenanthroline by H₂O₂

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this