Mechanism of action of volatile anesthetics: Effects of halothane on glutamate receptors in vitro

Misha Perouansky; Eilon D. Kirson; Yoel Yaari

doi:10.1016/S0378-4274(98)00166-0

Mechanism of action of volatile anesthetics: Effects of halothane on glutamate receptors in vitro

Misha Perouansky^*
, Eilon D. Kirson
, Yoel Yaari

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

(1) We have investigated the effect of halothane on glutamate receptor-mediated excitation in pyramidal cells and interneurons of the hippocampal CA1 area. (2) Halothane similarly inhibited non-NMDA and NMDA receptor-mediated excitatory postsynaptic currents in both cell types at low concentrations but preferentially blocked responses to exogenously applied AMPA at higher concentrations. (3) Synaptically but not directly evoked action potentials in interneurons were inhibited by halothane. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	65-69
Number of pages	5
Journal	Toxicology Letters
Volume	100-101
DOIs	https://doi.org/10.1016/S0378-4274(98)00166-0
State	Published - 23 Nov 1998

Keywords

Anesthetics, volatile
Animals, mouse
Brain, hippocampus
Central nervous system, excitatory postsynaptic currents
Halothane
Measurement technique, hippocampal slice, patch-clamp
Neuron, interneuron, pyramidal cell
Receptors, glutamate, N-methyl-d-aspartate, non-N-methyl-d-aspartate

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10.1016/S0378-4274(98)00166-0

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title = "Mechanism of action of volatile anesthetics: Effects of halothane on glutamate receptors in vitro",

abstract = "(1) We have investigated the effect of halothane on glutamate receptor-mediated excitation in pyramidal cells and interneurons of the hippocampal CA1 area. (2) Halothane similarly inhibited non-NMDA and NMDA receptor-mediated excitatory postsynaptic currents in both cell types at low concentrations but preferentially blocked responses to exogenously applied AMPA at higher concentrations. (3) Synaptically but not directly evoked action potentials in interneurons were inhibited by halothane. Copyright (C) 1998 Elsevier Science Ireland Ltd.",

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author = "Misha Perouansky and Kirson, \{Eilon D.\} and Yoel Yaari",

year = "1998",

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doi = "10.1016/S0378-4274(98)00166-0",

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T2 - Effects of halothane on glutamate receptors in vitro

AU - Perouansky, Misha

AU - Kirson, Eilon D.

AU - Yaari, Yoel

PY - 1998/11/23

Y1 - 1998/11/23

N2 - (1) We have investigated the effect of halothane on glutamate receptor-mediated excitation in pyramidal cells and interneurons of the hippocampal CA1 area. (2) Halothane similarly inhibited non-NMDA and NMDA receptor-mediated excitatory postsynaptic currents in both cell types at low concentrations but preferentially blocked responses to exogenously applied AMPA at higher concentrations. (3) Synaptically but not directly evoked action potentials in interneurons were inhibited by halothane. Copyright (C) 1998 Elsevier Science Ireland Ltd.

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KW - Anesthetics, volatile

KW - Animals, mouse

KW - Brain, hippocampus

KW - Central nervous system, excitatory postsynaptic currents

KW - Halothane

KW - Measurement technique, hippocampal slice, patch-clamp

KW - Neuron, interneuron, pyramidal cell

KW - Receptors, glutamate, N-methyl-d-aspartate, non-N-methyl-d-aspartate

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JO - Toxicology Letters

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ER -

Mechanism of action of volatile anesthetics: Effects of halothane on glutamate receptors in vitro

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