Abstract
Polyribosomes and mRNAs from normal and iron-treated rats were isolated, and their relative capacities for apoferritin synthesis in a cell-free system were measured. In vitro synthesis of apoferritin was 2-fold greater when polyribosomes or mRNA from iron-treated rats was used, whereas total protein synthesis was unchanged. This finding shows that one mechanism by which iron administration stimulates apoferritin synthesis is by increasing the amount of apoferritin mRNA in polyribosomes.
| Original language | English |
|---|---|
| Pages (from-to) | 583-90 |
| Number of pages | 8 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 65 |
| Issue number | 2 |
| DOIs | |
| State | Published - 22 Jul 1975 |
Keywords
- Animals
- Apoferritins/biosynthesis
- Cell-Free System
- Electrophoresis, Polyacrylamide Gel
- Enzyme Induction/drug effects
- Ferritins/biosynthesis
- Iron/pharmacology
- Leucine/metabolism
- Liver/drug effects
- Male
- Polyribosomes/drug effects
- Protein Biosynthesis/drug effects
- RNA, Messenger/metabolism
- Rats
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