Mechanisms and models of somatic cell reprogramming

Yosef Buganim, Dina A. Faddah, Rudolf Jaenisch*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

352 Scopus citations

Abstract

Conversion of somatic cells to pluripotency by defined factors is a long and complex process that yields embryonic-stem-cell-like cells that vary in their developmental potential. To improve the quality of resulting induced pluripotent stem cells (iPSCs), which is important for potential therapeutic applications, and to address fundamental questions about control of cell identity, molecular mechanisms of the reprogramming process must be understood. Here we discuss recent discoveries regarding the role of reprogramming factors in remodelling the genome, including new insights into the function of MYC, and describe the different phases, markers and emerging models of reprogramming.

Original languageAmerican English
Pages (from-to)427-439
Number of pages13
JournalNature Reviews Genetics
Volume14
Issue number6
DOIs
StatePublished - Jun 2013
Externally publishedYes

Bibliographical note

Funding Information:
We thank M. Dawlaty, A. Soufi and K. Zaret for insightful comments on the manuscript. Y.B. is supported by a US National Institutes of Health (NIH) Kirschstein National Research Service Award (1 F32 GM099153-01A1). D.A.F. is a Vertex Scholar and was supported by a US National Science Foundation Graduate Research Fellowship and Jerome and Florence Brill Graduate Student Fellowship. R.J. is supported by US NIH grants R37-CA084198 and RO1-CA087869.

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