Mechanisms of Nociceptive Transduction and Transmission: A Machinery for Pain Sensation and Tools for Selective Analgesia

Alexander M. Binshtok*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

16 Scopus citations

Abstract

Many surgical and dental procedures depend on use of local anesthetics to reversibly eliminate pain. By the blockade of voltage-gated sodium channels, local anesthetics prevent the transmission of nociceptive information. However, since all local anesthetics act non-selectively on all types of axons they also cause a loss of innocuous sensation, motor paralysis and autonomic block. Thus, approaches that produce only a selective blockade of pain fibers are of great potential clinical importance. In this chapter we will review the recent findings describing mechanisms of pain transduction and transmission and introduce novel therapeutic approaches to produce pain-selective analgesia.

Original languageAmerican English
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
Pages143-177
Number of pages35
DOIs
StatePublished - 2011

Publication series

NameInternational Review of Neurobiology
Volume97
ISSN (Print)0074-7742
ISSN (Electronic)0074-7742

Keywords

  • Inflammatory pain
  • Local anesthesia
  • Neuropathic pain
  • Nociception
  • QX-314
  • TRP
  • Targeted delivery
  • Voltage gated sodium channels

Fingerprint

Dive into the research topics of 'Mechanisms of Nociceptive Transduction and Transmission: A Machinery for Pain Sensation and Tools for Selective Analgesia'. Together they form a unique fingerprint.

Cite this