Mechanisms of stress-induced angiogenesis in tumours: Tumour Angiogenesis

Eli Keshet; Ilan Stein; Michal Neeman; Roy Bicknell; Claire E Lewis; Napoleone Ferrara

doi:10.1093/oso/9780198549376.003.0007

Mechanisms of stress-induced angiogenesis in tumours: Tumour Angiogenesis

Eli Keshet
, Ilan Stein
, Michal Neeman
, Roy Bicknell (Editor)
, Claire E Lewis (Editor)
, Napoleone Ferrara (Editor)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Tumour angiogenesis is generally viewed as the consequence of an ‘angiogenic switch’, i.e. a genetic event that endows the tumour with the ability to recruit blood vessels from the neighbouring tissue. Whether the up-regulation of angiogenesis stimulators (]) or the down-regulation of angiogenesis inhibitors (2), the ‘angiogenic switch’ is conceived as a stochastic event in the succession of genetic hits that underlie tumour progression.

Original language	American English
Title of host publication	Tumour Angiogenesis
Editors	Roy Bicknell, Claire E Lewis , Napoleone Ferrara
Publisher	Oxford University Press
Chapter	7
Pages	71–80
ISBN (Print)	9780198549376
DOIs	https://doi.org/10.1093/oso/9780198549376.003.0007
State	Published - 1997

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title = "Mechanisms of stress-induced angiogenesis in tumours: Tumour Angiogenesis",

abstract = "Tumour angiogenesis is generally viewed as the consequence of an {\textquoteleft}angiogenic switch{\textquoteright}, i.e. a genetic event that endows the tumour with the ability to recruit blood vessels from the neighbouring tissue. Whether the up-regulation of angiogenesis stimulators (]) or the down-regulation of angiogenesis inhibitors (2), the {\textquoteleft}angiogenic switch{\textquoteright} is conceived as a stochastic event in the succession of genetic hits that underlie tumour progression.",

author = "Eli Keshet and Ilan Stein and Michal Neeman and Roy Bicknell and Lewis, \{Claire E\} and Napoleone Ferrara",

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A2 - Lewis, Claire E

A2 - Ferrara, Napoleone

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A2 - Lewis , Claire E

A2 - Ferrara , Napoleone

PY - 1997

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AB - Tumour angiogenesis is generally viewed as the consequence of an ‘angiogenic switch’, i.e. a genetic event that endows the tumour with the ability to recruit blood vessels from the neighbouring tissue. Whether the up-regulation of angiogenesis stimulators (]) or the down-regulation of angiogenesis inhibitors (2), the ‘angiogenic switch’ is conceived as a stochastic event in the succession of genetic hits that underlie tumour progression.

U2 - 10.1093/oso/9780198549376.003.0007

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M3 - Chapter

SN - 9780198549376

SP - 71

EP - 80

BT - Tumour Angiogenesis

PB - Oxford University Press

ER -

Mechanisms of stress-induced angiogenesis in tumours: Tumour Angiogenesis

Abstract

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