Mechanisms of the Reactions of Some Copper Complexes in the Presence of DNA with O2-, H2O2, and Molecular Oxygen

Sara Goldstein, Gidon Czapski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

The kinetics and the reaction mechanism of some copper complexes of 1,10-phenanthroline, 5-nitro-l,10-phenanthroline, and 2,2’-bipyridine with O2-, H2O2, and O2in the presence of calf thymus DNA have been investigated with use of the pulse radiolysis technique. We have found that both copper(II) and copper(I) complexes bind to DNA. The ternary complexes react very slowly with O2- relative to the free complexes, while the rates of the oxidation of free and bound cuprous complexes by H2O2are almost the same. Therefore these ternary copper complexes turned out to be good catalysts of the reaction between O2- and H2O2.

Original languageEnglish
Pages (from-to)2244-2250
Number of pages7
JournalJournal of the American Chemical Society
Volume108
Issue number9
DOIs
StatePublished - 1986

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