TY - JOUR
T1 - Mechanisms of the Reactions of Some Copper Complexes in the Presence of DNA with O2-, H2O2, and Molecular Oxygen
AU - Goldstein, Sara
AU - Czapski, Gidon
PY - 1986
Y1 - 1986
N2 - The kinetics and the reaction mechanism of some copper complexes of 1,10-phenanthroline, 5-nitro-l,10-phenanthroline, and 2,2’-bipyridine with O2-, H2O2, and O2in the presence of calf thymus DNA have been investigated with use of the pulse radiolysis technique. We have found that both copper(II) and copper(I) complexes bind to DNA. The ternary complexes react very slowly with O2- relative to the free complexes, while the rates of the oxidation of free and bound cuprous complexes by H2O2are almost the same. Therefore these ternary copper complexes turned out to be good catalysts of the reaction between O2- and H2O2.
AB - The kinetics and the reaction mechanism of some copper complexes of 1,10-phenanthroline, 5-nitro-l,10-phenanthroline, and 2,2’-bipyridine with O2-, H2O2, and O2in the presence of calf thymus DNA have been investigated with use of the pulse radiolysis technique. We have found that both copper(II) and copper(I) complexes bind to DNA. The ternary complexes react very slowly with O2- relative to the free complexes, while the rates of the oxidation of free and bound cuprous complexes by H2O2are almost the same. Therefore these ternary copper complexes turned out to be good catalysts of the reaction between O2- and H2O2.
UR - http://www.scopus.com/inward/record.url?scp=33845374174&partnerID=8YFLogxK
U2 - 10.1021/ja00269a020
DO - 10.1021/ja00269a020
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AN - SCOPUS:33845374174
SN - 0002-7863
VL - 108
SP - 2244
EP - 2250
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 9
ER -