Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase

Keyphrases

• Pseudomonas Aeruginosa (P. aeruginosa) 100%
• Synthetic Inhibitors 100%
• Quorum Sensing Molecules 100%
• Mechanistic Analysis 100%
• LasI 100%
• Biofilm Formation 40%
• N-acyl Homoserine Lactone 40%
• Circuitry 20%
• Hydrogen Bonds (H-bonds) 20%
• Double mutant 20%
• Cell Signaling 20%
• Two-site 20%
• Quorum Sensing 20%
• Novel Inhibitors 20%
• High Affinity 20%
• Bacterial Growth 20%
• Site-directed mutagenesis 20%
• Drug Target 20%
• In Silico 20%
• Mechanistic Approach 20%
• Signal Production 20%
• Human Infection 20%
• Virulence Determinants 20%
• In Silico Docking 20%
• Swarming Motility 20%
• 4-dione 20%
• Gram-negative Pathogens 20%
• LuxI 20%
• Thiazolidinediones 20%

Chemistry

• Biofilm Formation 100%
• % Inhibition 100%
• Homoserine Lactone 100%
• Structure 50%
• Hydrogen Bonding 50%
• Site-Directed Mutagenesis 50%
• Compound Type 50%
• Drug Target 50%

Immunology and Microbiology

• Quorum Sensing 100%
• Pseudomonas aeruginosa 100%
• Biofilm 50%
• Computer Model 50%
• Homoserine 50%
• Infectious Agent 25%
• Signal Transduction 25%
• Site Directed Mutagenesis 25%
• Bacterial Growth 25%
• Hydrogen Bond 25%
• Swarming Motility 25%