TY - JOUR
T1 - Medical cannabis utilization in children – a study based on a nationwide cohort
AU - Treves, Nir
AU - Yakirevich-Amir, Noa
AU - Allegaert, Karel
AU - van den Anker, John N.
AU - Kohn, Elkana
AU - Berlin, Maya
AU - Hazan, Ariela
AU - Davidson, Elyad
AU - Berkovitch, Matitiahu
AU - Bonne, Omer
AU - Stolar, Orit E.
AU - Matok, Ilan
N1 - Publisher Copyright:
Copyright © 2025 Treves, Yakirevich-Amir, Allegaert, van den Anker, Kohn, Berlin, Hazan, Davidson, Berkovitch, Bonne, Stolar and Matok.
PY - 2025
Y1 - 2025
N2 - Introduction: This study aimed to evaluate the utilization of medical cannabis in a pediatric population and compare short-term persistence rates with those in adolescents and young adults. Methods: In this retrospective, nationwide cohort study supplemented by data from an open-label study of children with ASD, patient cases under 12 years of age who received medical cannabis treatment between 2018 and 2022 were analyzed. The primary outcome assessed was treatment persistence within the first 3 months. Secondary outcomes included changes in THC ratios, amounts dispensed, and reasons for treatment discontinuation. Results: The patient population consisted of 1,341 children using medical cannabis for ASD (751), epilepsy (330), Tourette syndrome (165), and pediatric cancer (95). Out of 3,007 consecutive medical cannabis sessions, the adjusted hazard ratio for discontinuation in the first 3 months was 0.83 (95% CI [0.71–0.96], p = 0.01) for young adults compared to children. Approximately 60%–70% of children discontinued therapy within the first 6 months. Significant alterations in THC ratios or dispensed amounts were observed in most sessions within the initial 6 months. In the open-label study dataset, most treatment discontinuations were primarily attributed to adverse effects and a perceived lack of therapeutic efficacy. Conclusion: Our findings suggest that short-term persistence of medical cannabis therapy is lower in children compared to adolescents and young adults. Moreover, many pediatric patients required adjustments to their THC ratios and showed a high frequency of treatment discontinuation. These observations underscore the importance of targeted strategies to improve medical cannabis treatment effectiveness and adherence in the pediatric population. Although MC may offer therapeutic benefits for pediatric patients, our findings emphasize the importance of careful patient selection and close medical follow-up to optimize clinical outcomes.
AB - Introduction: This study aimed to evaluate the utilization of medical cannabis in a pediatric population and compare short-term persistence rates with those in adolescents and young adults. Methods: In this retrospective, nationwide cohort study supplemented by data from an open-label study of children with ASD, patient cases under 12 years of age who received medical cannabis treatment between 2018 and 2022 were analyzed. The primary outcome assessed was treatment persistence within the first 3 months. Secondary outcomes included changes in THC ratios, amounts dispensed, and reasons for treatment discontinuation. Results: The patient population consisted of 1,341 children using medical cannabis for ASD (751), epilepsy (330), Tourette syndrome (165), and pediatric cancer (95). Out of 3,007 consecutive medical cannabis sessions, the adjusted hazard ratio for discontinuation in the first 3 months was 0.83 (95% CI [0.71–0.96], p = 0.01) for young adults compared to children. Approximately 60%–70% of children discontinued therapy within the first 6 months. Significant alterations in THC ratios or dispensed amounts were observed in most sessions within the initial 6 months. In the open-label study dataset, most treatment discontinuations were primarily attributed to adverse effects and a perceived lack of therapeutic efficacy. Conclusion: Our findings suggest that short-term persistence of medical cannabis therapy is lower in children compared to adolescents and young adults. Moreover, many pediatric patients required adjustments to their THC ratios and showed a high frequency of treatment discontinuation. These observations underscore the importance of targeted strategies to improve medical cannabis treatment effectiveness and adherence in the pediatric population. Although MC may offer therapeutic benefits for pediatric patients, our findings emphasize the importance of careful patient selection and close medical follow-up to optimize clinical outcomes.
KW - cannabidiol
KW - delta-9-tetrahydrocannabinol
KW - developmental pharmacology
KW - pediatrics
KW - pharmacovigilance
UR - https://www.scopus.com/pages/publications/105023993356
U2 - 10.3389/fphar.2025.1646560
DO - 10.3389/fphar.2025.1646560
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C2 - 41357860
AN - SCOPUS:105023993356
SN - 1663-9812
VL - 16
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 1646560
ER -