TY - JOUR
T1 - Membrane-protein phosphorylation in the Bacillus subtilis cell cycle
AU - Sandler, Naomi
AU - Keynan, Alex
PY - 1992/8/15
Y1 - 1992/8/15
N2 - Sphingosine, an inhibitor of Ca2+-dependent protein kinases in eukaryotic cells, inhibited initiation of DNA replication in Bacillus subtilis at a concentration of 10 μM, without inhibiting elongation. The tumor promoter 12-tetradecanoyl 13-phorbol acetate, (TPA), an activator of protein kinase C in eukaryotic cells, partially counteracted the inhibition of initiation by sphingosine. Phosphorylation of polypeptides was observed in vivo at initiation of DNA replication in B. subtilis. Sphingosine, TPA, and vancomycin affected this protein phosphorylation.
AB - Sphingosine, an inhibitor of Ca2+-dependent protein kinases in eukaryotic cells, inhibited initiation of DNA replication in Bacillus subtilis at a concentration of 10 μM, without inhibiting elongation. The tumor promoter 12-tetradecanoyl 13-phorbol acetate, (TPA), an activator of protein kinase C in eukaryotic cells, partially counteracted the inhibition of initiation by sphingosine. Phosphorylation of polypeptides was observed in vivo at initiation of DNA replication in B. subtilis. Sphingosine, TPA, and vancomycin affected this protein phosphorylation.
KW - Bacillus
KW - Cell cycle
KW - Membrane
KW - Phosphorylation
UR - http://www.scopus.com/inward/record.url?scp=0026695121&partnerID=8YFLogxK
U2 - 10.1016/0378-1097(92)90436-R
DO - 10.1016/0378-1097(92)90436-R
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C2 - 1526457
AN - SCOPUS:0026695121
SN - 0378-1097
VL - 95
SP - 241
EP - 246
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 2-3
ER -