Memory and motor control in patients with psychogenic nonepileptic seizures

A. Dienstag; S. Ben-Naim; M. Gilad; Dana Ekstein; Shahar Arzy; Renana Eitan

doi:10.1016/j.yebeh.2019.07.026

Memory and motor control in patients with psychogenic nonepileptic seizures

A. Dienstag, S. Ben-Naim, M. Gilad, Dana Ekstein, Shahar Arzy, Renana Eitan^*

^*Corresponding author for this work

Department of Medical Neurobiology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Psychogenic nonepileptic seizures (PNES) are of the most elusive phenomena in epileptology. Patients with PNES present episodes resembling epileptic seizures in their semiology yet lacking the underlying epileptic brain activity. These episodes are assumed to be related to psychological distress from past trauma, yet the underlying mechanism of this manifestation is still unknown. Using resting-state functional magnetic resonance imaging (fMRI), we investigated functional connectivity changes within and between large-scale brain networks in 9 patients with PNES, compared with a group of 13 age- and gender-matched healthy controls. Functional magnetic resonance imaging analyses identified functional connectivity disturbances between the medial temporal lobe (MTL) and the sensorimotor cortex and between the MTL and ventral attention networks in patients with PNES. Within network connectivity reduction was found within the visual network. Our findings suggest that PNES relate to changes in connectivity in between areas that are involved in memory processing and motor activity and attention control. These results may shed new light on the way by which traumatic memories may relate to PNES.

Original language	English
Pages (from-to)	279-284
Number of pages	6
Journal	Epilepsy and Behavior
Volume	98
DOIs	https://doi.org/10.1016/j.yebeh.2019.07.026
State	Published - Sep 2019

Bibliographical note

Funding Information:
Acknowledgments: This study was supported by The Israel Science Foundation and the Prusiner?Abramsky Award by the Orion Foundation to S.A. We thank our patients for their kind agreement to participate in the study, and staff of the Magnetic Resonance Imaging unit, Neurology and Psychiatry Departments of Hadassah Medical Center for their help in patient management.? Acknowledgments: This study was supported by The Israel Science Foundation and the Prusiner?Abramsky Award by the Orion Foundation to S.A. We thank our patients for their kind agreement to participate in the study, and staff of the Magnetic Resonance Imaging unit, Neurology and Psychiatry Departments of Hadassah Medical Center for their help in patient management.

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

Connectivity
Functional MRI
Functional disorders
Psychosomatics
fMRI

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title = "Memory and motor control in patients with psychogenic nonepileptic seizures",

abstract = "Psychogenic nonepileptic seizures (PNES) are of the most elusive phenomena in epileptology. Patients with PNES present episodes resembling epileptic seizures in their semiology yet lacking the underlying epileptic brain activity. These episodes are assumed to be related to psychological distress from past trauma, yet the underlying mechanism of this manifestation is still unknown. Using resting-state functional magnetic resonance imaging (fMRI), we investigated functional connectivity changes within and between large-scale brain networks in 9 patients with PNES, compared with a group of 13 age- and gender-matched healthy controls. Functional magnetic resonance imaging analyses identified functional connectivity disturbances between the medial temporal lobe (MTL) and the sensorimotor cortex and between the MTL and ventral attention networks in patients with PNES. Within network connectivity reduction was found within the visual network. Our findings suggest that PNES relate to changes in connectivity in between areas that are involved in memory processing and motor activity and attention control. These results may shed new light on the way by which traumatic memories may relate to PNES.",

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AU - Eitan, Renana

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N2 - Psychogenic nonepileptic seizures (PNES) are of the most elusive phenomena in epileptology. Patients with PNES present episodes resembling epileptic seizures in their semiology yet lacking the underlying epileptic brain activity. These episodes are assumed to be related to psychological distress from past trauma, yet the underlying mechanism of this manifestation is still unknown. Using resting-state functional magnetic resonance imaging (fMRI), we investigated functional connectivity changes within and between large-scale brain networks in 9 patients with PNES, compared with a group of 13 age- and gender-matched healthy controls. Functional magnetic resonance imaging analyses identified functional connectivity disturbances between the medial temporal lobe (MTL) and the sensorimotor cortex and between the MTL and ventral attention networks in patients with PNES. Within network connectivity reduction was found within the visual network. Our findings suggest that PNES relate to changes in connectivity in between areas that are involved in memory processing and motor activity and attention control. These results may shed new light on the way by which traumatic memories may relate to PNES.

AB - Psychogenic nonepileptic seizures (PNES) are of the most elusive phenomena in epileptology. Patients with PNES present episodes resembling epileptic seizures in their semiology yet lacking the underlying epileptic brain activity. These episodes are assumed to be related to psychological distress from past trauma, yet the underlying mechanism of this manifestation is still unknown. Using resting-state functional magnetic resonance imaging (fMRI), we investigated functional connectivity changes within and between large-scale brain networks in 9 patients with PNES, compared with a group of 13 age- and gender-matched healthy controls. Functional magnetic resonance imaging analyses identified functional connectivity disturbances between the medial temporal lobe (MTL) and the sensorimotor cortex and between the MTL and ventral attention networks in patients with PNES. Within network connectivity reduction was found within the visual network. Our findings suggest that PNES relate to changes in connectivity in between areas that are involved in memory processing and motor activity and attention control. These results may shed new light on the way by which traumatic memories may relate to PNES.

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Memory and motor control in patients with psychogenic nonepileptic seizures

Abstract

Bibliographical note

Keywords

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