Mental-orientation: A new approach to assessing patients across the Alzheimer's disease spectrum

Gregory Peters-Founshtein, Michael Peer, Yanai Rein, Shlomzion Kahana Merhavi, Zeev Meiner, Shahar Arzy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Objective: This study aims to assess the role of mental-orientation in the diagnosis of mild cognitive impairment and Alzheimer's disease using a novel task. Method: A behavioral study (Experiment 1) compared the mental-orientation task to standard neuropsychological tests in patients across the Alzheimer's disease spectrum. A functional MRI study (Experiment 2) in young adults compared activations evoked by the mental-orientation and standard-orientation tasks as well as their overlap with brain regions susceptible to Alzheimer's disease pathology. Results: The mental-orientation task differentiated mild cognitively impaired and healthy controls at 95% accuracy, while the Addenbrooke's Cognitive Examination, Mini-Mental State Examination and standard-orientation achieved 74%, 70% and 50% accuracy, respectively. Functional MRI revealed the mental-orientation task to preferentially recruit brain regions exhibiting early Alzheimer's-related atrophy, unlike the standard-orientation test. Conclusions: Mental-orientation is suggested to play a key role in Alzheimer's disease, and consequently in early detection and follow-up of patients along the Alzheimer's disease spectrum.

Original languageAmerican English
Pages (from-to)690-699
Number of pages10
JournalNeuropsychology
Volume32
Issue number6
DOIs
StatePublished - Sep 2018

Bibliographical note

Funding Information:
We thank Mor Nitzan for guidance in machine-learning analyses, and Tamir Ben-Hur and JP Newman for important discussions. The study was supported by the Israeli Science Foundation and the Alzheimer’s Foundation of America.

Publisher Copyright:
© 2018 American Psychological Association.

Keywords

  • Alzheimer's disease
  • Functional magnetic resonance imaging
  • Mild cognitive impairment
  • Orientation

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