Mercuration of tryptophan in luteinizing hormone-releasing hormone

E. Hazum, M. Fridkin*, R. Meidan, Y. Koch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

1. 1. The indole moiety of tryptophan in luteinizing hormone-releasing hormone (LH-RH) was selectively mercurated by mercuric acetate, yielding [Trp3-(acetoxymercury)n]-LH-RH (n = 1.15 2.01) derivatives. 2. 2. The ultraviolet spectra of the indole-modified peptides showed an average red shift of 4-6 nm (λ280 to λ284-6), while the molar extinction coefficients were usually increased, and often by ∼ 50-75%. 3. 3. The luteinizing hormone-releasing activity of various mercurated LH-RH preparations ranged between 25% to 120% of that of the native hormone.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalInternational Journal of Biochemistry
Volume9
Issue number6
DOIs
StatePublished - 1978
Externally publishedYes

Fingerprint

Dive into the research topics of 'Mercuration of tryptophan in luteinizing hormone-releasing hormone'. Together they form a unique fingerprint.

Cite this