TY - JOUR
T1 - Mercuration of tryptophan in luteinizing hormone-releasing hormone
AU - Hazum, E.
AU - Fridkin, M.
AU - Meidan, R.
AU - Koch, Y.
PY - 1978
Y1 - 1978
N2 - 1. 1. The indole moiety of tryptophan in luteinizing hormone-releasing hormone (LH-RH) was selectively mercurated by mercuric acetate, yielding [Trp3-(acetoxymercury)n]-LH-RH (n = 1.15 2.01) derivatives. 2. 2. The ultraviolet spectra of the indole-modified peptides showed an average red shift of 4-6 nm (λ280 to λ284-6), while the molar extinction coefficients were usually increased, and often by ∼ 50-75%. 3. 3. The luteinizing hormone-releasing activity of various mercurated LH-RH preparations ranged between 25% to 120% of that of the native hormone.
AB - 1. 1. The indole moiety of tryptophan in luteinizing hormone-releasing hormone (LH-RH) was selectively mercurated by mercuric acetate, yielding [Trp3-(acetoxymercury)n]-LH-RH (n = 1.15 2.01) derivatives. 2. 2. The ultraviolet spectra of the indole-modified peptides showed an average red shift of 4-6 nm (λ280 to λ284-6), while the molar extinction coefficients were usually increased, and often by ∼ 50-75%. 3. 3. The luteinizing hormone-releasing activity of various mercurated LH-RH preparations ranged between 25% to 120% of that of the native hormone.
UR - https://www.scopus.com/pages/publications/0018100359
U2 - 10.1016/0020-711X(78)90050-2
DO - 10.1016/0020-711X(78)90050-2
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C2 - 352765
AN - SCOPUS:0018100359
SN - 0020-711X
VL - 9
SP - 385
EP - 388
JO - International Journal of Biochemistry
JF - International Journal of Biochemistry
IS - 6
ER -