Mercuration of tryptophan in luteinizing hormone-releasing hormone

E. Hazum; M. Fridkin; R. Meidan; Y. Koch

doi:10.1016/0020-711X(78)90050-2

Mercuration of tryptophan in luteinizing hormone-releasing hormone

E. Hazum
, M. Fridkin^*
, R. Meidan
, Y. Koch

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

1. 1. The indole moiety of tryptophan in luteinizing hormone-releasing hormone (LH-RH) was selectively mercurated by mercuric acetate, yielding [Trp³-(acetoxymercury)n]-LH-RH (n = 1.15 2.01) derivatives. 2. 2. The ultraviolet spectra of the indole-modified peptides showed an average red shift of 4-6 nm (λ₂₈₀ to λ_284-6), while the molar extinction coefficients were usually increased, and often by ∼ 50-75%. 3. 3. The luteinizing hormone-releasing activity of various mercurated LH-RH preparations ranged between 25% to 120% of that of the native hormone.

Original language	English
Pages (from-to)	385-388
Number of pages	4
Journal	International Journal of Biochemistry
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/0020-711X(78)90050-2
State	Published - 1978
Externally published	Yes

Access to Document

10.1016/0020-711X(78)90050-2

Cite this

@article{972c198f90394009938119c4db833aa1,

title = "Mercuration of tryptophan in luteinizing hormone-releasing hormone",

abstract = "1. 1. The indole moiety of tryptophan in luteinizing hormone-releasing hormone (LH-RH) was selectively mercurated by mercuric acetate, yielding [Trp3-(acetoxymercury)n]-LH-RH (n = 1.15 2.01) derivatives. 2. 2. The ultraviolet spectra of the indole-modified peptides showed an average red shift of 4-6 nm (λ280 to λ284-6), while the molar extinction coefficients were usually increased, and often by ∼ 50-75\%. 3. 3. The luteinizing hormone-releasing activity of various mercurated LH-RH preparations ranged between 25\% to 120\% of that of the native hormone.",

author = "E. Hazum and M. Fridkin and R. Meidan and Y. Koch",

year = "1978",

doi = "10.1016/0020-711X(78)90050-2",

language = "אנגלית",

volume = "9",

pages = "385--388",

journal = "International Journal of Biochemistry",

issn = "0020-711X",

number = "6",

}

TY - JOUR

T1 - Mercuration of tryptophan in luteinizing hormone-releasing hormone

AU - Hazum, E.

AU - Fridkin, M.

AU - Meidan, R.

AU - Koch, Y.

PY - 1978

Y1 - 1978

N2 - 1. 1. The indole moiety of tryptophan in luteinizing hormone-releasing hormone (LH-RH) was selectively mercurated by mercuric acetate, yielding [Trp3-(acetoxymercury)n]-LH-RH (n = 1.15 2.01) derivatives. 2. 2. The ultraviolet spectra of the indole-modified peptides showed an average red shift of 4-6 nm (λ280 to λ284-6), while the molar extinction coefficients were usually increased, and often by ∼ 50-75%. 3. 3. The luteinizing hormone-releasing activity of various mercurated LH-RH preparations ranged between 25% to 120% of that of the native hormone.

AB - 1. 1. The indole moiety of tryptophan in luteinizing hormone-releasing hormone (LH-RH) was selectively mercurated by mercuric acetate, yielding [Trp3-(acetoxymercury)n]-LH-RH (n = 1.15 2.01) derivatives. 2. 2. The ultraviolet spectra of the indole-modified peptides showed an average red shift of 4-6 nm (λ280 to λ284-6), while the molar extinction coefficients were usually increased, and often by ∼ 50-75%. 3. 3. The luteinizing hormone-releasing activity of various mercurated LH-RH preparations ranged between 25% to 120% of that of the native hormone.

UR - https://www.scopus.com/pages/publications/0018100359

U2 - 10.1016/0020-711X(78)90050-2

DO - 10.1016/0020-711X(78)90050-2

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 352765

AN - SCOPUS:0018100359

SN - 0020-711X

VL - 9

SP - 385

EP - 388

JO - International Journal of Biochemistry

JF - International Journal of Biochemistry

IS - 6

ER -

Mercuration of tryptophan in luteinizing hormone-releasing hormone

Abstract

Access to Document

Other files and links

Fingerprint

Cite this