Merging C-H and C-C bond cleavage in organic synthesis

Zackaria Nairoukh*, Morgan Cormier, Ilan Marek

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

133 Scopus citations

Abstract

Metal-catalysed functionalization of a carbon-hydrogen bond can occur selectively even in the presence of ostensibly more reactive functional groups. Such conversions have changed our perceptions of organic chemistry because we can now consider a C-H bond as a functional group, the reactions of which are among the most attractive and powerful means to rapidly add complexity. Another versatile tool in organic synthesis is the metal-catalysed selective cleavage of C-C bonds. Applying both expedient methods in a tandem process would give us an ideal approach to synthesizing complex molecular architectures. The challenge lies in ensuring that the reactions do not interfere with each other; the simultaneous control of both C-H and C-C bond activations is the subject of this Review. The reactions that meet this challenge and enable a selective merger of C-H and C-C bond activations in a one-pot process are discussed. Their realization could afford sophisticated molecular fragments that are otherwise difficult to access.

Original languageAmerican English
Article number0035
JournalNature Reviews Chemistry
Volume1
DOIs
StatePublished - 11 Jan 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Macmillan Publishers Limited.

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