Merging data curation and machine learning to improve nanomedicines

Chen Chen, Zvi Yaari, Elana Apfelbaum, Piotr Grodzinski, Yosi Shamay, Daniel A. Heller*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Nanomedicine design is often a trial-and-error process, and the optimization of formulations and in vivo properties requires tremendous benchwork. To expedite the nanomedicine research progress, data science is steadily gaining importance in the field of nanomedicine. Recently, efforts have explored the potential to predict nanomaterials synthesis and biological behaviors via advanced data analytics. Machine learning algorithms process large datasets to understand and predict various material properties in nanomedicine synthesis, pharmacologic parameters, and efficacy. “Big data” approaches may enable even larger advances, especially if researchers capitalize on data curation methods. However, the concomitant use of data curation processes needed to facilitate the acquisition and standardization of large, heterogeneous data sets, to support advanced data analytics methods such as machine learning has yet to be leveraged. Currently, data curation and data analytics areas of nanotechnology-focused data science, or 'nanoinformatics', have been proceeding largely independently. This review highlights the current efforts in both areas and the potential opportunities for coordination to advance the capabilities of data analytics in nanomedicine.

Original languageAmerican English
Article number114172
JournalAdvanced Drug Delivery Reviews
StatePublished - Apr 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 Elsevier B.V.


  • Artificial intelligence
  • Cancer therapeutics
  • Data curation
  • Nanoparticles, data mining
  • Nanotechnology
  • Particle characterization


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