Abstract
The authors review the current status of research on mesenchymal stem cells (MSCs), a plastic-adherent cell population that can be directed to differentiate in vitro into cells of osteogenic, chondrogenic, adipogenic, myogenic, and other lineages. Characteristics of MSCs that lend to their being used in stem cell applications are described. Various tissues containing MSCs are specified and the methods by which these cells can be isolated are explicated. The relationship between MSCs and the immune system are discussed. In addition, the authors offer a review of current knowledge of MSC exomes and their place in stem cell–driven therapy, as well as a discussion of induced pluripotent stem cell–derived MSCs.
| Original language | English |
|---|---|
| Title of host publication | Principles of Regenerative Medicine |
| Publisher | Elsevier |
| Pages | 205-218 |
| Number of pages | 14 |
| ISBN (Electronic) | 9780128098806 |
| ISBN (Print) | 9780128098936 |
| DOIs | |
| State | Published - 1 Jan 2018 |
Bibliographical note
Publisher Copyright:© 2019 Elsevier Inc. All rights reserved.
Keywords
- Exosomes
- Immunoisolation
- MSC immunomodulation
- Mesenchymal stem cells (MSCs)
- Stemness
- iMSCs
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