“Messieurs, c’est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells

Chamutal Gur, Ofer Mandelboim*, Gilad Bachrach

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.

Original languageAmerican English
Pages (from-to)1-3
Number of pages3
JournalOncoImmunology
Volume4
Issue number9
DOIs
StatePublished - 1 Jan 2015

Bibliographical note

Publisher Copyright:
© 2015 Taylor & Francis Group, LLC.

Keywords

  • Colon adenocarcinoma
  • Fusobacteria
  • NK cells
  • Tumor immunity

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