“Messieurs, c’est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells

Chamutal Gur; Ofer Mandelboim; Gilad Bachrach

doi:10.1080/2162402X.2015.1038690

“Messieurs, c’est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells

Chamutal Gur, Ofer Mandelboim^*, Gilad Bachrach

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	OncoImmunology
Volume	4
Issue number	9
DOIs	https://doi.org/10.1080/2162402X.2015.1038690
State	Published - 1 Jan 2015

Bibliographical note

Publisher Copyright:
© 2015 Taylor & Francis Group, LLC.

Keywords

Colon adenocarcinoma
Fusobacteria
NK cells
Tumor immunity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/2162402X.2015.1038690

Cite this

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title = "“Messieurs, c{\textquoteright}est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells",

abstract = "Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.",

keywords = "Colon adenocarcinoma, Fusobacteria, NK cells, Tumor immunity",

author = "Chamutal Gur and Ofer Mandelboim and Gilad Bachrach",

note = "Publisher Copyright: {\textcopyright} 2015 Taylor \& Francis Group, LLC.",

year = "2015",

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day = "1",

doi = "10.1080/2162402X.2015.1038690",

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“Messieurs, c’est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells. / Gur, Chamutal; Mandelboim, Ofer ; Bachrach, Gilad.
In: OncoImmunology, Vol. 4, No. 9, 01.01.2015, p. 1-3.

Research output: Contribution to journal › Article › peer-review

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AU - Gur, Chamutal

AU - Mandelboim, Ofer

AU - Bachrach, Gilad

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.

AB - Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.

KW - Colon adenocarcinoma

KW - Fusobacteria

KW - NK cells

KW - Tumor immunity

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“Messieurs, c’est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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