Metabolism and autophagy in plants—a perfect match

Sahar Magen, Heike Seybold, Daniel Laloum, Tamar Avin-Wittenberg*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Autophagy is a eukaryotic cellular transport mechanism that delivers intracellular macromolecules, proteins, and even organelles to a lytic organelle (vacuole in yeast and plants/lysosome in animals) for degradation and nutrient recycling. The process is mediated by highly conserved autophagy-related (ATG) proteins. In plants, autophagy maintains cellular homeostasis under favorable conditions, guaranteeing normal plant growth and fitness. Severe stress such as nutrient starvation and plant senescence further induce it, thus ensuring plant survival under unfavorable conditions by providing nutrients through the removal of damaged or aged proteins, or organelles. In this article, we examine the interplay between metabolism and autophagy, focusing on the different aspects of this reciprocal relationship. We show that autophagy has a strong influence on a range of metabolic processes, whereas at the same time, even single metabolites can activate autophagy. We highlight the involvement of ATG genes in metabolism, examine the role of the macronutrients carbon and nitrogen, and various micronutrients, and take a closer look at how the interaction between autophagy and metabolism impacts on plant phenotypes and yield.

Original languageAmerican English
Pages (from-to)2133-2151
Number of pages19
JournalFEBS Letters
Volume596
Issue number17
DOIs
StatePublished - Sep 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

Keywords

  • ATG genes
  • Arabidopsis
  • autophagy
  • carbon
  • crops
  • metabolism
  • micronutrients
  • nitrogen
  • plant
  • yield

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