Metastatic carcinoma presenting with concomitant eosinophilia and thromboembolism

Zvi G. Fridlender; Hans Uwe Simon; Meir Shalit

doi:10.1097/00000441-200308000-00008

Metastatic carcinoma presenting with concomitant eosinophilia and thromboembolism

Zvi G. Fridlender^*, Hans Uwe Simon, Meir Shalit

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A case of a 58-year-old female patient who presented with significant blood eosinophilia and thromboembolic events is described. The patient was eventually diagnosed as suffering from a disseminated malignancy of gastrointestinal origin. Immunohistochemical studies of the tumor are presented. These studies show that tumor cells produce interleukin-3 and -5 and granulocyte macrophage-colony stimulating factor. These cytokines are known to support differentiation, proliferation, and survival of eosinophils. Their secretion is the probable explanation for the appearance of high blood eosinophilia in this patient. To the best of our knowledge, combined blood eosinophilia and thromboembolism as presenting manifestations of a solid tumor have never been reported.

Original language	English
Pages (from-to)	98-101
Number of pages	4
Journal	American Journal of the Medical Sciences
Volume	326
Issue number	2
DOIs	https://doi.org/10.1097/00000441-200308000-00008
State	Published - 1 Aug 2003
Externally published	Yes

Bibliographical note

Funding Information:
This work was partially supported by the Bernische Krebsliga (Bern, Switzerland).

Keywords

Cytokines
Eosinophilia
Malignancy
Paraneoplasia
Thromboembolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/00000441-200308000-00008

Cite this

@article{e151aa632ad146c09461d4abf0752233,

title = "Metastatic carcinoma presenting with concomitant eosinophilia and thromboembolism",

abstract = "A case of a 58-year-old female patient who presented with significant blood eosinophilia and thromboembolic events is described. The patient was eventually diagnosed as suffering from a disseminated malignancy of gastrointestinal origin. Immunohistochemical studies of the tumor are presented. These studies show that tumor cells produce interleukin-3 and -5 and granulocyte macrophage-colony stimulating factor. These cytokines are known to support differentiation, proliferation, and survival of eosinophils. Their secretion is the probable explanation for the appearance of high blood eosinophilia in this patient. To the best of our knowledge, combined blood eosinophilia and thromboembolism as presenting manifestations of a solid tumor have never been reported.",

keywords = "Cytokines, Eosinophilia, Malignancy, Paraneoplasia, Thromboembolism",

author = "Fridlender, {Zvi G.} and Simon, {Hans Uwe} and Meir Shalit",

note = "Funding Information: This work was partially supported by the Bernische Krebsliga (Bern, Switzerland). ",

year = "2003",

month = aug,

day = "1",

doi = "10.1097/00000441-200308000-00008",

language = "אנגלית",

volume = "326",

pages = "98--101",

journal = "American Journal of the Medical Sciences",

issn = "0002-9629",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "2",

}

TY - JOUR

T1 - Metastatic carcinoma presenting with concomitant eosinophilia and thromboembolism

AU - Fridlender, Zvi G.

AU - Simon, Hans Uwe

AU - Shalit, Meir

N1 - Funding Information: This work was partially supported by the Bernische Krebsliga (Bern, Switzerland).

PY - 2003/8/1

Y1 - 2003/8/1

N2 - A case of a 58-year-old female patient who presented with significant blood eosinophilia and thromboembolic events is described. The patient was eventually diagnosed as suffering from a disseminated malignancy of gastrointestinal origin. Immunohistochemical studies of the tumor are presented. These studies show that tumor cells produce interleukin-3 and -5 and granulocyte macrophage-colony stimulating factor. These cytokines are known to support differentiation, proliferation, and survival of eosinophils. Their secretion is the probable explanation for the appearance of high blood eosinophilia in this patient. To the best of our knowledge, combined blood eosinophilia and thromboembolism as presenting manifestations of a solid tumor have never been reported.

AB - A case of a 58-year-old female patient who presented with significant blood eosinophilia and thromboembolic events is described. The patient was eventually diagnosed as suffering from a disseminated malignancy of gastrointestinal origin. Immunohistochemical studies of the tumor are presented. These studies show that tumor cells produce interleukin-3 and -5 and granulocyte macrophage-colony stimulating factor. These cytokines are known to support differentiation, proliferation, and survival of eosinophils. Their secretion is the probable explanation for the appearance of high blood eosinophilia in this patient. To the best of our knowledge, combined blood eosinophilia and thromboembolism as presenting manifestations of a solid tumor have never been reported.

KW - Cytokines

KW - Eosinophilia

KW - Malignancy

KW - Paraneoplasia

KW - Thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=0043028591&partnerID=8YFLogxK

U2 - 10.1097/00000441-200308000-00008

DO - 10.1097/00000441-200308000-00008

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 12920442

AN - SCOPUS:0043028591

SN - 0002-9629

VL - 326

SP - 98

EP - 101

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

IS - 2

ER -

Metastatic carcinoma presenting with concomitant eosinophilia and thromboembolism

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this