Metformin-Induced Lactic Acidosis Associated with Acute Renal Failure

Rifaat Safadi*, Michal Dranitzki-Elhalel, Mordecai Popovtzer, Arie Ben-Yehuda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


A 69-year-old diabetic woman with diffuse atherosclerosis presented withacute renal failure due to contrast nephropathy and severe metformin-induced lactic acidosis. There was a discrepancy between the patient’s elevated serumcreatinine level, indicative of severe renal insufficiency, and her very low bloodurea nitrogen content. It is postulated that the patient’s extremely severe acidosis interfered with her hepatic urea generation, contributing to this unusual biochemical abnormality.

Original languageAmerican English
Pages (from-to)520-522
Number of pages3
JournalAmerican Journal of Nephrology
Issue number6
StatePublished - 1 Jan 1996
Externally publishedYes


  • Lactic acidosis
  • Metformin
  • Renal failure
  • Urea cycle


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