Metformin-Induced Lactic Acidosis Associated with Acute Renal Failure

Rifaat Safadi; Michal Dranitzki-Elhalel; Mordecai Popovtzer; Arie Ben-Yehuda

doi:10.1159/000169052

Metformin-Induced Lactic Acidosis Associated with Acute Renal Failure

Rifaat Safadi^*, Michal Dranitzki-Elhalel, Mordecai Popovtzer, Arie Ben-Yehuda

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A 69-year-old diabetic woman with diffuse atherosclerosis presented withacute renal failure due to contrast nephropathy and severe metformin-induced lactic acidosis. There was a discrepancy between the patient’s elevated serumcreatinine level, indicative of severe renal insufficiency, and her very low bloodurea nitrogen content. It is postulated that the patient’s extremely severe acidosis interfered with her hepatic urea generation, contributing to this unusual biochemical abnormality.

Original language	English
Pages (from-to)	520-522
Number of pages	3
Journal	American Journal of Nephrology
Volume	16
Issue number	6
DOIs	https://doi.org/10.1159/000169052
State	Published - 1 Jan 1996
Externally published	Yes

Keywords

Lactic acidosis
Metformin
Renal failure
Urea cycle

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10.1159/000169052

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AU - Ben-Yehuda, Arie

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KW - Urea cycle

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Metformin-Induced Lactic Acidosis Associated with Acute Renal Failure

Abstract

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