Methionine-centered redox cycle in organs of the aero-digestive tract of young and old rats

Vladimir Vinokur, Leonid Grinberg, Eduard Berenshtein, Menachem Gross, Jackob Moskovitz, Abraham Z. Reznick, Mordechai Chevion*, Ron Eliashar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

It is commonly accepted that aging is associated with a decline in the antioxidant defense of the cell; accordingly, certain redox enzymes are used as markers of biological senescence. To further test and specify this general concept, we studied age-related changes in the enzymes of the methionine-centered redox cycle (MCRC) in four aero-digestive organs of rats. The levels of cytosolic thioredoxin (Trx), thioredoxin reductase (TrxR), and methionine sulfoxide reductase (Msr), all tended to decline with age. The enzymatic activities of MsrA and MsrB were significantly lower in the organs of aged animals. In general, the magnitude of this decline increased in the order: tongue < sternohyoid muscle < larynx < esophagus. The relative stability of MCRC in the old tongues might be part of the well-preserved oxidative metabolism as confirmed by the age-related increase in mitochondrial marker and muscle tissue in these tongues. In total, the results suggest that age-associated oxidative damage is organ-specific and could reflect differences in morphological composition of these tissues, and among them, relative content of striated muscles.

Original languageAmerican English
Pages (from-to)43-52
Number of pages10
JournalBiogerontology
Volume10
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgments This research was supported by research grants from the Dr. Avraham Moshe and Pepka Bergman Memorial Fund and from the Israel Science Foundation (585/ 02 and 316/05).

Keywords

  • Aging
  • Esophagus
  • Larynx
  • Methionine
  • Sternohyoid muscle
  • Thioredoxin
  • Tongue

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