Method for antiglaucoma drug screening on rabbits

M. Blumenthal; S. Yankelev; S. Dikstein

doi:10.1159/000264831

Method for antiglaucoma drug screening on rabbits

M. Blumenthal
, S. Yankelev
, S. Dikstein^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

α-Chymotrypsin-induced elevation of intraocular pressure in rabbits was found to be a suitable model for the screening of potential antiglaucoma agents. Pilocarpine shows minimal active concentration at 0.001% and adrenaline at 0.00001%, (-)Δ₆-tetrahydrocannabinol at 0.001%.

Original language	English
Pages (from-to)	259-261
Number of pages	3
Journal	Ophthalmic Research
Volume	8
Issue number	4
DOIs	https://doi.org/10.1159/000264831
State	Published - 1976

Keywords

(-)Δ<inf>6</inf>-Tetrahydrocannabinol
Adrenaline
Antiglaucoma
Pilocarpine
Screening
α-Chymotrypsin

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10.1159/000264831

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title = "Method for antiglaucoma drug screening on rabbits",

abstract = "α-Chymotrypsin-induced elevation of intraocular pressure in rabbits was found to be a suitable model for the screening of potential antiglaucoma agents. Pilocarpine shows minimal active concentration at 0.001\% and adrenaline at 0.00001\%, (-)Δ6-tetrahydrocannabinol at 0.001\%.",

keywords = "(-)Δ<inf>6</inf>-Tetrahydrocannabinol, Adrenaline, Antiglaucoma, Pilocarpine, Screening, α-Chymotrypsin",

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doi = "10.1159/000264831",

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AU - Yankelev, S.

AU - Dikstein, S.

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AB - α-Chymotrypsin-induced elevation of intraocular pressure in rabbits was found to be a suitable model for the screening of potential antiglaucoma agents. Pilocarpine shows minimal active concentration at 0.001% and adrenaline at 0.00001%, (-)Δ6-tetrahydrocannabinol at 0.001%.

KW - (-)Δ<inf>6</inf>-Tetrahydrocannabinol

KW - Adrenaline

KW - Antiglaucoma

KW - Pilocarpine

KW - Screening

KW - α-Chymotrypsin

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JO - Ophthalmic Research

JF - Ophthalmic Research

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Method for antiglaucoma drug screening on rabbits

Abstract

Keywords

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