Methodologies for target selection in structural genomics

Michal Linial*, Golan Yona

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

As the number of complete genomes that have been sequenced keeps growing, unknown areas of the protein space are revealed and new horizons open up. Most of this information will be fully appreciated only when the structural information about the encoded proteins becomes available. The goal of structural genomics is to direct large-scale efforts of protein structure determination, so as to increase the impact of these efforts. This review focuses on current approaches in structural genomics aimed at selecting representative proteins as targets for structure determination. We will discuss the concept of representative structures/folds, the current methodologies for identifying those proteins, and computational techniques for identifying proteins which are expected to adopt new structural folds. (C) 2000 Elsevier Science Ltd.

Original languageAmerican English
Pages (from-to)297-320
Number of pages24
JournalProgress in Biophysics and Molecular Biology
Volume73
Issue number5
DOIs
StatePublished - 2000

Bibliographical note

Funding Information:
This study was partially supported by the Israeli Academy of Science (Initiatives in Res. in Sc. & Technology) and the Horowitz Fund. Golan Yona is supported by a Burroughs-Welcome Fellowship from the Program in Mathematics and Molecular Biology (PMMB).

Keywords

  • Clustering
  • Computational method
  • Databases
  • Fold recognition
  • Protein families
  • Protein fold
  • Protein sequences
  • Protein structure determination

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