Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction

Ido Sagi; Shiran Bar; Nissim Benvenisty

doi:10.1016/j.stem.2018.10.012

Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction

Ido Sagi, Shiran Bar, Nissim Benvenisty^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting. Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting.

Original language	American English
Pages (from-to)	625-627
Number of pages	3
Journal	Cell Stem Cell
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2018.10.012
State	Published - 1 Nov 2018

Bibliographical note

Funding Information:
N.B. is CSO of NewStem Ltd.

Publisher Copyright:
© 2018 Elsevier Inc.

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10.1016/j.stem.2018.10.012

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title = "Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction",

abstract = "Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting. Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting.",

author = "Ido Sagi and Shiran Bar and Nissim Benvenisty",

note = "Funding Information: N.B. is CSO of NewStem Ltd. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

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T2 - CRISPRing Out the Barriers for Unisexual Reproduction

AU - Sagi, Ido

AU - Bar, Shiran

AU - Benvenisty, Nissim

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Y1 - 2018/11/1

N2 - Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting. Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting.

AB - Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting. Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting.

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Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction

Abstract

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