Abstract
Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting. Genomic imprinting results in the molecular and functional inequality of maternal and paternal alleles, precluding mammalian unisexual development. In this issue of Cell Stem Cell, Li et al. (2018) employ sophisticated manipulations of gametes and engineered haploid embryonic stem cells to successfully generate both all-maternal and all-paternal mice, effectively overcoming the roadblocks of imprinting.
Original language | American English |
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Pages (from-to) | 625-627 |
Number of pages | 3 |
Journal | Cell Stem Cell |
Volume | 23 |
Issue number | 5 |
DOIs | |
State | Published - 1 Nov 2018 |
Bibliographical note
Funding Information:N.B. is CSO of NewStem Ltd.
Publisher Copyright:
© 2018 Elsevier Inc.