TY - JOUR
T1 - Microbial sensor cell arrays
AU - Melamed, Sahar
AU - Elad, Tal
AU - Belkin, Shimshon
PY - 2012/2
Y1 - 2012/2
N2 - Motivated by the advantages endowed by high-throughput analysis, researchers have succeeded in incorporating multiple reporter cells into a single platform; the technology now allows the simultaneous scrutiny of a large collection of sensor strains. We review current aspects in cell array technology with emphasis on microbial sensor arrays. We consider various techniques for patterning live cells on solid surfaces, describe different array-based applications and devices, and highlight recent efforts for live cell storage. We review mathematical approaches for deciphering the data emanating from bioreporter collections, and discuss the future of single cell arrays. Innovative technologies for cell patterning, preservation and interpretation are continuously being developed; when they all mature, cell arrays may become an efficient analytical tool, in a scope resembling that of DNA microarray biochips.
AB - Motivated by the advantages endowed by high-throughput analysis, researchers have succeeded in incorporating multiple reporter cells into a single platform; the technology now allows the simultaneous scrutiny of a large collection of sensor strains. We review current aspects in cell array technology with emphasis on microbial sensor arrays. We consider various techniques for patterning live cells on solid surfaces, describe different array-based applications and devices, and highlight recent efforts for live cell storage. We review mathematical approaches for deciphering the data emanating from bioreporter collections, and discuss the future of single cell arrays. Innovative technologies for cell patterning, preservation and interpretation are continuously being developed; when they all mature, cell arrays may become an efficient analytical tool, in a scope resembling that of DNA microarray biochips.
UR - http://www.scopus.com/inward/record.url?scp=84856442159&partnerID=8YFLogxK
U2 - 10.1016/j.copbio.2011.11.024
DO - 10.1016/j.copbio.2011.11.024
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C2 - 22176747
AN - SCOPUS:84856442159
SN - 0958-1669
VL - 23
SP - 2
EP - 8
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 1
ER -