TY - JOUR
T1 - Microemulsion-facilitated ccrystallization of carbamazepine
AU - Kogan, Anna
AU - Popov, Inna
AU - Uvarov, Vladimir
AU - Cohen, Shmuel
AU - Aserin, Abraham
AU - Garti, Nissim
PY - 2007/9
Y1 - 2007/9
N2 - The crystallization patterns of carbamazepine precipitated from a confined microemulsion reservoir were studied by DSC, TGA, Powder XRD, single crystal XRD, SEM, and optical microscopy. The results suggest that interfacial fast nucleation and slow growth from O/W microemulsion leads to a selective, large, and better-ordered single crystals of dihydrate form with primitive monoclinic unit cell with parameters a = 10.16 Å, b = 28.70 Å, c = 4.93 Å, β = 103.33°, cell volume of 1400.7 Å3, and space group P21/c. The crystal structure, as well as the habit, are strongly influenced by the heat dissipation and prefered molecular orientation at the interface.
AB - The crystallization patterns of carbamazepine precipitated from a confined microemulsion reservoir were studied by DSC, TGA, Powder XRD, single crystal XRD, SEM, and optical microscopy. The results suggest that interfacial fast nucleation and slow growth from O/W microemulsion leads to a selective, large, and better-ordered single crystals of dihydrate form with primitive monoclinic unit cell with parameters a = 10.16 Å, b = 28.70 Å, c = 4.93 Å, β = 103.33°, cell volume of 1400.7 Å3, and space group P21/c. The crystal structure, as well as the habit, are strongly influenced by the heat dissipation and prefered molecular orientation at the interface.
KW - Carbamazepine
KW - Crystallization
KW - Dehydrate
KW - Microemulsion
KW - Polymorph
UR - http://www.scopus.com/inward/record.url?scp=34548697308&partnerID=8YFLogxK
U2 - 10.1080/01932690701522418
DO - 10.1080/01932690701522418
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AN - SCOPUS:34548697308
SN - 0193-2691
VL - 28
SP - 1008
EP - 1019
JO - Journal of Dispersion Science and Technology
JF - Journal of Dispersion Science and Technology
IS - 7
ER -
