Microencapsulation of dichromate and paracetamol with Eudragit Retard polymers using phase separation by nonsolvent addition

M. Donbrow*, S. Benita, A. Hoffman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A coacervation technique for microencapsulation using Eudragit Retard polymers [poly(methyl methacrylates) substituted by quaternary ammonium groups] as wall material is described, based upon phase separation using a cold chloroform-cyclohexane mixture together with polyisobutylene as a stabilizer. The effect of various parameters on the nature and properties of the microcapsules of potassium dichromate and paracetamol has been studied, in particular the alteration in wall content and structure and release rate of contents. The microcapsules are discrete, their properties are reproducible, and various degrees of sustained release are obtained.

Original languageAmerican English
Pages (from-to)245-249
Number of pages5
JournalApplied Biochemistry and Biotechnology
Volume10
Issue number1-3
DOIs
StatePublished - Feb 1984

Keywords

  • Microencapsulation, by phase separation
  • dichromate, microencapsulation of
  • microcapsules, using Eudragit Retard [poly(methyl methacrylate) derivatives]
  • paracetamol microcapsules
  • phase separation, in microencapsulation

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