Microglia, seen from the CX3CR1 angle

Yochai Wolf; Simon Yona; Ki Wook Kim; Steffen Jung

doi:10.3389/fncel.2013.00026

Microglia, seen from the CX₃CR1 angle

Yochai Wolf, Simon Yona, Ki Wook Kim, Steffen Jung^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

246 Scopus citations

Abstract

Microglial cells in brain and spinal cord are characterized by high expression of the chemokine receptor CX₃CR1. Expression of the sole CX₃CR1 ligand, the membrane-tethered and sheddable chemokine CX₃CL1/fractalkine, is restricted in the brain parenchyma to selected neurons. Here we summarize our current understanding of the physiological role of CX₃CR1 for microglia function and the CX₃C axis in microglial/neuronal crosstalk in homeostasis and under challenge. Moreover, we will discuss the efforts of our laboratory and others to exploit CX₃CR1 promoter activity for the visualization and genetic manipulation of microglia to probe their functional contributions in the central nerve system (CNS) context.

Original language	English
Journal	Frontiers in Cellular Neuroscience
Issue number	MAR
DOIs	https://doi.org/10.3389/fncel.2013.00026
State	Published - 18 Mar 2013
Externally published	Yes

Keywords

CXCR1
Cre-loxP knock-in mice
Microglia
Neuroimmunology
Neuropathology

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10.3389/fncel.2013.00026

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abstract = "Microglial cells in brain and spinal cord are characterized by high expression of the chemokine receptor CX3CR1. Expression of the sole CX3CR1 ligand, the membrane-tethered and sheddable chemokine CX3CL1/fractalkine, is restricted in the brain parenchyma to selected neurons. Here we summarize our current understanding of the physiological role of CX3CR1 for microglia function and the CX3C axis in microglial/neuronal crosstalk in homeostasis and under challenge. Moreover, we will discuss the efforts of our laboratory and others to exploit CX3CR1 promoter activity for the visualization and genetic manipulation of microglia to probe their functional contributions in the central nerve system (CNS) context.",

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AB - Microglial cells in brain and spinal cord are characterized by high expression of the chemokine receptor CX3CR1. Expression of the sole CX3CR1 ligand, the membrane-tethered and sheddable chemokine CX3CL1/fractalkine, is restricted in the brain parenchyma to selected neurons. Here we summarize our current understanding of the physiological role of CX3CR1 for microglia function and the CX3C axis in microglial/neuronal crosstalk in homeostasis and under challenge. Moreover, we will discuss the efforts of our laboratory and others to exploit CX3CR1 promoter activity for the visualization and genetic manipulation of microglia to probe their functional contributions in the central nerve system (CNS) context.

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Microglia, seen from the CX₃CR1 angle

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Keywords

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